Shankar Raj Devkota
Overview
Explore the profile of Shankar Raj Devkota including associated specialties, affiliations and a list of published articles.
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9
Citations
42
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Recent Articles
1.
Hussain K, Lim H, Devkota S, Kemp-Harper B, Lane J, Canals M, et al.
PLoS One
. 2024 Sep;
19(9):e0305312.
PMID: 39259753
The primate-specific chemokine CCL18 is a potent chemoattractant for T cells and is expressed at elevated levels in several inflammatory diseases. However, the cognate receptor for CCL18 remains unconfirmed. Here,...
2.
Devkota S, Aryal P, Wilce M, Payne R, Stone M, Bhusal R
Protein Sci
. 2024 May;
33(6):e4999.
PMID: 38723106
Ticks produce chemokine-binding proteins, known as evasins, in their saliva to subvert the host's immune response. Evasins bind to chemokines and thereby inhibit the activation of their cognate chemokine receptors,...
3.
Jha S, De Rubis G, Devkota S, Zhang Y, Adhikari R, Jha L, et al.
Ageing Res Rev
. 2024 Apr;
97:102315.
PMID: 38679394
Lung cancer stands as the primary contributor to cancer-related fatalities worldwide, affecting both genders. Two primary types exist where non-small cell lung cancer (NSCLC), accounts for 80-85% and SCLC accounts...
4.
Devkota S, Aryal P, Pokhrel R, Jiao W, Perry A, Panjikar S, et al.
Nat Commun
. 2023 Jul;
14(1):4204.
PMID: 37452046
Chemokines are key regulators of leukocyte trafficking and attractive targets for anti-inflammatory therapy. Evasins are chemokine-binding proteins from tick saliva, whose application as anti-inflammatory therapeutics will require manipulation of their...
5.
Aryal P, Devkota S, Jeevarajah D, Law R, Payne R, Bhusal R, et al.
J Biol Chem
. 2022 Aug;
298(10):102382.
PMID: 35973511
Class A tick evasins are natural chemokine-binding proteins that block the signaling of multiple chemokines from the CC subfamily through their cognate receptors, thus suppressing leukocyte recruitment and inflammation. Development...
6.
Bhusal R, Aryal P, Devkota S, Pokhrel R, Gunzburg M, Foster S, et al.
Proc Natl Acad Sci U S A
. 2022 Feb;
119(9).
PMID: 35217625
As natural chemokine inhibitors, evasin proteins produced in tick saliva are potential therapeutic agents for numerous inflammatory diseases. Engineering evasins to block the desired chemokines and avoid off-target side effects...
7.
Sai K, Chhetri S, Devkota S, Khatri D
ScientificWorldJournal
. 2021 Jul;
2021:3230351.
PMID: 34257624
(L.f.) Kurz. (family: Anacardiaceae) is a wild deciduous tree indigenous to southeast Asian countries. Different parts of this plant are used traditionally for the treatment and cure of various disorders...
8.
Kwon E, Devkota S, Pathak D, Dahal P, Kim D
PLoS One
. 2019 Aug;
14(8):e0221666.
PMID: 31461489
Sigma factors are key proteins that mediate the recruitment of RNA polymerase to the promoter regions of genes, for the initiation of bacterial transcription. Multiple sigma factors in a bacterium...
9.
Devkota S, Kwon E, Ha S, Chang H, Kim D
PLoS One
. 2017 Mar;
12(3):e0174284.
PMID: 28319136
Bacillus subtilis SigW is localized to the cell membrane and is inactivated by the tight interaction with anti-sigma RsiW under normal growth conditions. Whereas SigW is discharged from RsiW binding...