Shane M Wilkinson
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Explore the profile of Shane M Wilkinson including associated specialties, affiliations and a list of published articles.
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12
Citations
271
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Recent Articles
1.
Janssen B, Vugts D, Wilkinson S, Ory D, Chalon S, Hoozemans J, et al.
Sci Rep
. 2018 Apr;
8(1):6580.
PMID: 29700413
The P2X receptor plays a significant role in microglial activation, and as a potential drug target, the P2X receptor is also an interesting target in positron emission tomography. The current...
2.
Pharmacological Evaluation of Novel Bioisosteres of an Adamantanyl Benzamide P2X Receptor Antagonist
Wilkinson S, Barron M, OBrien-Brown J, Janssen B, Stokes L, Werry E, et al.
ACS Chem Neurosci
. 2017 Aug;
8(11):2374-2380.
PMID: 28841278
Adamantanyl benzamide 1 was identified as a potent P2XR antagonist but failed to progress further due to poor metabolic stability. We describe the synthesis and SAR of a series of...
3.
Reekie T, Wilkinson S, Law V, Hibbs D, Ong J, Kassiou M
Org Biomol Chem
. 2016 Dec;
15(3):576-580.
PMID: 27991628
Preparation of N-(indol-2-yl)amides and N-(indol-3-yl)amides are scarce in the scientific literature due to unstable intermediates impeding current reported syntheses. We have employed cheap and readily available substrates in the Curtius...
4.
Conroy T, Manohar M, Gong Y, Wilkinson S, Webster M, Lieberman B, et al.
Org Biomol Chem
. 2016 Oct;
14(39):9388-9405.
PMID: 27714195
The sigma-1 receptor (S1R) has attracted a great deal of attention as a prospective drug target due to its involvement in numerous neurological disorders and, more recently, for its therapeutic...
5.
Banister S, Moir M, Stuart J, Kevin R, Wood K, Longworth M, et al.
ACS Chem Neurosci
. 2015 Jul;
6(9):1546-59.
PMID: 26134475
Synthetic cannabinoid (SC) designer drugs based on indole and indazole scaffolds and featuring l-valinamide or l-tert-leucinamide side chains are encountered with increasing frequency by forensic researchers and law enforcement agencies...
6.
Banister S, Stuart J, Kevin R, Edington A, Longworth M, Wilkinson S, et al.
ACS Chem Neurosci
. 2015 Apr;
6(8):1445-58.
PMID: 25921407
Synthetic cannabinoid (SC) designer drugs featuring bioisosteric fluorine substitution are identified by forensic chemists and toxicologists with increasing frequency. Although terminal fluorination of N-pentyl indole SCs is sometimes known to...
7.
Banister S, Beinat C, Wilkinson S, Shen B, Bartoli C, Selleri S, et al.
Eur J Med Chem
. 2015 Mar;
93:392-400.
PMID: 25725375
Sixteen new phenyl alkyl ether derivatives (12, 14-28) of the 5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-ylacetamide (DPA) class were synthesized and evaluated in a competition binding assay against [(3)H]PK11195 using 18 kDa translocator protein (TSPO)...
8.
Wilkinson S, Gunosewoyo H, Barron M, Boucher A, McDonnell M, Turner P, et al.
ACS Chem Neurosci
. 2014 Apr;
5(5):335-9.
PMID: 24689484
Relative to other polycyclic frameworks (1-3), a carborane cage (4 and Cs·5) exerts a significant biological effect as an inhibitor of the purinergic P2X7 receptor (P2X7R) which allows one to...
9.
Banister S, Wilkinson S, Longworth M, Stuart J, Apetz N, English K, et al.
ACS Chem Neurosci
. 2013 Apr;
4(7):1081-92.
PMID: 23551277
Two novel adamantane derivatives, adamantan-1-yl(1-pentyl-1H-indol-3-yl)methanone (AB-001) and N-(adamtan-1-yl)-1-pentyl-1H-indole-3-carboxamide (SDB-001), were recently identified as cannabimimetic indoles of abuse. Conflicting anecdotal reports of the psychoactivity of AB-001 in humans, and a complete...
10.
Boutin H, Prenant C, Maroy R, Galea J, Greenhalgh A, Smigova A, et al.
PLoS One
. 2013 Feb;
8(2):e56441.
PMID: 23418569
Purpose: Neuroinflammation is involved in several brain disorders and can be monitored through expression of the translocator protein 18 kDa (TSPO) on activated microglia. In recent years, several new PET...