Shanbo Yang
Overview
Explore the profile of Shanbo Yang including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
49
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Recent Articles
1.
Xiu Y, Zhang Y, Yang S, Shi L, Xing D, Wang C
Front Chem
. 2024 Aug;
12:1447831.
PMID: 39119517
In this work, a series of new diarylpyrimidine derivatives as microtubule destabilizers were designed, synthesized, and evaluated for anticancer activities. Based on restriction configuration strategy, we introduced the pyrimidine moiety...
2.
Wang C, Zhang Y, Yang S, Shi L, Rong R, Zhang T, et al.
J Enzyme Inhib Med Chem
. 2024 Jan;
39(1):2302320.
PMID: 38221788
A new series of 1-pyrrolo[3,2-]pyridine derivatives were designed and synthesised as colchicine-binding site inhibitors. Preliminary biological evaluations showed that most of the target compounds displayed moderate to excellent antitumor activities...
3.
Wang C, Zhang Y, Yang S, Shi L, Xiu Y, Wu Y, et al.
J Enzyme Inhib Med Chem
. 2023 Dec;
39(1):2286939.
PMID: 38083880
A series of restricted 3-aryl-4-(3,4,5-trimethoxyphenyl)pyridines as novel tubulin polymerisation inhibitors was designed based on molecular docking. Compound , exhibited potent antiproliferative activity against HeLa, MCF-7, and A549 cell lines. Mechanism...
4.
Wang C, Shi L, Yang S, Chang J, Liu W, Zeng J, et al.
Front Chem
. 2023 Mar;
11:1096666.
PMID: 36936533
Cancer threatens human health and life. Therefore, it is particularly important to develop safe and effective antitumor drugs. Microtubules, the main component of cytoskeleton, play an important role in maintaining...
5.
Wang C, Yang S, Deng J, Shi L, Chang J, Meng J, et al.
Drug Dev Res
. 2023 Feb;
84(3):458-469.
PMID: 36744648
Phytopharmaceuticals have attracted a lot of attention due to their multicomponent and multiple targets. The natural phenolic chemicals known as flavonoids are found in a wide variety of plants, fruits,...
6.
Wang C, Chang J, Yang S, Shi L, Zhang Y, Liu W, et al.
Front Chem
. 2022 Nov;
10:1040333.
PMID: 36385996
Combretastatin A-4 (CA-4) is a potent inhibitor of tubulin polymerization and a colchicine binding site inhibitor (CBSI). The structure-activity relationship study of CA-4 showed that the double bond configuration and...
7.
Zeng J, Liu W, Liang B, Shi L, Yang S, Meng J, et al.
Molecules
. 2022 Nov;
27(21).
PMID: 36364321
Isoliquiritigenin (ISL) is a flavonoid with a chalcone structure extracted from the natural herb . Its anti-inflammatory, antibacterial, antioxidant, and anticancer activities have been extensively studied. Moreover, ISL also possess...
8.
Liu W, Liang B, Zeng J, Meng J, Shi L, Yang S, et al.
Molecules
. 2022 Oct;
27(19).
PMID: 36234807
Elevated cholesterol significantly increases the risk of developing atherosclerosis and coronary heart disease. The key to treating hypercholesterolemia is lowering plasma cholesterol levels. There have been no studies on the...
9.
Yang S, Wang C, Shi L, Chang J, Zhang Y, Meng J, et al.
J Enzyme Inhib Med Chem
. 2022 Oct;
37(1):2755-2764.
PMID: 36196773
A set of novel diarylpyridines as anti-tubulin agents were designed, synthesised using a rigid pyridine as a linker to fix the -orientation of ring-A and ring-B. All of the target...
10.
Shi L, Yang S, Chang J, Zhang Y, Liu W, Zeng J, et al.
Front Chem
. 2022 Oct;
10:1004835.
PMID: 36186601
A series of new 9-aryl-5-pyrido[4,3-]indole derivatives as tubulin polymerization inhibitors were designed, synthesized, and evaluated for antitumor activity. All newly prepared compounds were tested for their anti-proliferative activity against three...