Shamith Samarajiwa
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Explore the profile of Shamith Samarajiwa including associated specialties, affiliations and a list of published articles.
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12
Citations
3499
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Recent Articles
1.
Xavier J, Magno R, Russell R, de Almeida B, Jacinta-Fernandes A, Besouro-Duarte A, et al.
Sci Rep
. 2024 Sep;
14(1):22526.
PMID: 39341862
Understanding breast cancer genetic risk relies on identifying causal variants and candidate target genes in risk loci identified by genome-wide association studies (GWAS), which remains challenging. Since most loci fall...
2.
Zecchini V, Paupe V, Herranz-Montoya I, Janssen J, Wortel I, Morris J, et al.
Nature
. 2023 Mar;
615(7952):499-506.
PMID: 36890229
Mutations in fumarate hydratase (FH) cause hereditary leiomyomatosis and renal cell carcinoma. Loss of FH in the kidney elicits several oncogenic signalling cascades through the accumulation of the oncometabolite fumarate....
3.
Neuron type-specific increase in lamin B1 contributes to nuclear dysfunction in Huntington's disease
Alcala-Vida R, Garcia-Forn M, Castany-Pladevall C, Creus-Muncunill J, Ito Y, Blanco E, et al.
EMBO Mol Med
. 2020 Dec;
13(2):e12105.
PMID: 33369245
Lamins are crucial proteins for nuclear functionality. Here, we provide new evidence showing that increased lamin B1 levels contribute to the pathophysiology of Huntington's disease (HD), a CAG repeat-associated neurodegenerative...
4.
Shorthouse D, Riedel A, Kerr E, Pedro L, Bihary D, Samarajiwa S, et al.
Nat Commun
. 2018 Aug;
9(1):3011.
PMID: 30069015
Osmotic regulation is a vital homoeostatic process in all cells and tissues. Cells initially respond to osmotic stresses by activating transmembrane transport proteins to move osmotically active ions. Disruption of...
5.
Turrell F, Kerr E, Gao M, Thorpe H, Doherty G, Cridge J, et al.
Genes Dev
. 2017 Aug;
31(13):1339-1353.
PMID: 28790158
Lung adenocarcinoma accounts for ∼40% of lung cancers, the leading cause of cancer-related death worldwide, and current therapies provide only limited survival benefit. Approximately half of lung adenocarcinomas harbor mutations...
6.
Hu Z, Mao J, Curtis C, Huang G, Gu S, Heiser L, et al.
Breast Cancer Res
. 2017 Feb;
19(1):17.
PMID: 28183333
No abstract available.
7.
Hu Z, Mao J, Curtis C, Huang G, Gu S, Heiser L, et al.
Breast Cancer Res
. 2016 Jul;
18(1):70.
PMID: 27368372
Background: High mitotic activity is associated with the genesis and progression of many cancers. Small molecule inhibitors of mitotic apparatus proteins are now being developed and evaluated clinically as anticancer...
8.
Curtis C, Shah S, Chin S, Turashvili G, Rueda O, Dunning M, et al.
Nature
. 2012 Apr;
486(7403):346-52.
PMID: 22522925
The elucidation of breast cancer subgroups and their molecular drivers requires integrated views of the genome and transcriptome from representative numbers of patients. We present an integrated analysis of copy...
9.
Maia A, Antoniou A, OReilly M, Samarajiwa S, Dunning M, Kartsonaki C, et al.
Breast Cancer Res
. 2012 Apr;
14(2):R63.
PMID: 22513257
Introduction: Cis-acting regulatory single nucleotide polymorphisms (SNPs) at specific loci may modulate penetrance of germline mutations at the same loci by introducing different levels of expression of the wild-type allele....
10.
Harman A, Lai J, Turville S, Samarajiwa S, Gray L, Marsden V, et al.
Blood
. 2011 Mar;
118(2):298-308.
PMID: 21411754
Many viruses have developed mechanisms to evade the IFN response. Here, HIV-1 was shown to induce a distinct subset of IFN-stimulated genes (ISGs) in monocyte-derived dendritic cells (DCs), without detectable...