Shagun Krishna
Overview
Explore the profile of Shagun Krishna including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
124
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Recent Articles
1.
Ehrlich D, Krishna S, Kleinstreuer N
ALTEX
. 2024 Jul;
41(4):617-632.
PMID: 38979646
Dysregulation of vascular endothelial growth factor (VEGF) and its receptor (VEGFR) contributes to atherosclerosis and cardiovascular disease (CVD), making it a potential target for CVD risk assessment. High-throughput screening (HTS)...
2.
Maurya P, Rawat R, Gupta S, Krishna S, Siddiqi M, Sashidhara K, et al.
J Biomol Struct Dyn
. 2024 Jan;
43(7):3390-3405.
PMID: 38179981
DNA topoisomerase 1 (Topo 1) is a pivotal player in various DNA processes, including replication, repair, and transcription. It serves as a target for anticancer drugs like camptothecin and its...
3.
Krishna S, Borrel A, Huang R, Zhao J, Xia M, Kleinstreuer N
Biology (Basel)
. 2022 Feb;
11(2).
PMID: 35205076
Chemical inhibition of the human ether-a -go-go-related gene (hERG) potassium channel leads to a prolonged QT interval that can contribute to severe cardiotoxicity. The adverse effects of hERG inhibition are...
4.
Krishna S, Berridge B, Kleinstreuer N
Chem Res Toxicol
. 2020 Dec;
34(2):566-583.
PMID: 33346635
Cardiovascular (CV) disease is one of the most prevalent public health concerns, and mounting evidence supports the contribution of environmental chemicals to CV disease burden. In this study, we performed...
5.
Krishna S, Lakra A, Shukla N, Khan S, Mishra D, Ahmed S, et al.
J Biomol Struct Dyn
. 2019 Aug;
38(11):3280-3295.
PMID: 31411124
Histone Deacetylases (HDACs) play a significant role in the regulation of gene expression by modifying histones and non-histone substrates. Since they are key regulators in the reversible epigenetic mechanism, they...
6.
Krishna S, Kumar S, Singh D, Lakra A, Banerjee D, Siddiqi M
Mol Inform
. 2018 Apr;
37(8):e1700150.
PMID: 29683269
The histone acetyl transferase (HAT) are involved in acetylation of histones that lead to transcription activation in numerous gene regulatory mechanisms. There are very few GCN5 HAT inhibitors reported despite...
7.
Mandalapu D, Kushwaha B, Gupta S, Krishna S, Srivastava N, Shukla M, et al.
Eur J Med Chem
. 2017 Dec;
143:632-645.
PMID: 29216562
Sexually transmitted diseases like trichomoniasis along with opportunistic fungal infections like candidiasis are major global health burden in female reproductive health. In this context a novel non-nitroimidazole class of substituted...
8.
Gupta S, Maurya P, Upadhyay A, Kushwaha P, Krishna S, Siddiqi M, et al.
Eur J Med Chem
. 2017 Nov;
143:1981-1996.
PMID: 29146133
DNA replication and repair are complex processes accomplished by the concerted action of a network of enzymes and proteins. DNA ligases play a crucial role in these processes by catalyzing...
9.
Hussain M, Singh D, Singh A, Asad M, Ansari M, Shameem M, et al.
Sci Rep
. 2017 Sep;
7(1):10715.
PMID: 28878282
Existing cancer therapies are often associated with drug resistance and toxicity, which results in poor prognosis and recurrence of cancer. This necessitates the identification and development of novel therapeutics against...
10.
Krishna S, Shukla S, Lakra A, Meeran S, Siddiqi M
J Mol Graph Model
. 2017 Jun;
75:174-188.
PMID: 28582695
DNA methylation is an epigenetic change that results in the addition of a methyl group at the carbon-5 position of cytosine residues. DNA methyltransferase (DNMT) inhibitors can suppress tumour growth...