Shadrielle Melijah G Espiritu
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Explore the profile of Shadrielle Melijah G Espiritu including associated specialties, affiliations and a list of published articles.
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6
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628
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Recent Articles
1.
Arbet J, Yamaguchi T, Shiah Y, Hugh-White R, Wiggins A, Oh J, et al.
bioRxiv
. 2025 Feb;
PMID: 39990314
Prostate cancer is characterized by profound heterogeneity in its clinical trajectory. While genomic heterogeneity has been well-characterized, epigenomic heterogeneity remains less understood. To fill this gap, we compiled 2,149 multi-ancestric...
2.
Yamaguchi T, Houlahan K, Zhu H, Kurganovs N, Livingstone J, Fox N, et al.
Cancer Discov
. 2025 Feb;
PMID: 39945744
Newly diagnosed prostate cancers differ dramatically in mutational composition and lethality. The most accurate clinical predictor of lethality is tumor tissue architecture, quantified as tumor grade. To interrogate the evolutionary...
3.
Salcedo A, Tarabichi M, Espiritu S, Deshwar A, David M, Wilson N, et al.
Nat Biotechnol
. 2020 Jan;
38(1):97-107.
PMID: 31919445
Tumor DNA sequencing data can be interpreted by computational methods that analyze genomic heterogeneity to infer evolutionary dynamics. A growing number of studies have used these approaches to link cancer...
4.
Houlahan K, Shiah Y, Gusev A, Yuan J, Ahmed M, Shetty A, et al.
Nat Med
. 2019 Oct;
25(10):1615-1626.
PMID: 31591588
Oncogenesis is driven by germline, environmental and stochastic factors. It is unknown how these interact to produce the molecular phenotypes of tumors. We therefore quantified the influence of germline polymorphisms...
5.
Lee A, Ewing A, Ellrott K, Hu Y, Houlahan K, Bare J, et al.
Genome Biol
. 2018 Nov;
19(1):188.
PMID: 30400818
Background: The phenotypes of cancer cells are driven in part by somatic structural variants. Structural variants can initiate tumors, enhance their aggressiveness, and provide unique therapeutic opportunities. Whole-genome sequencing of...
6.
Espiritu S, Liu L, Rubanova Y, Bhandari V, Holgersen E, Szyca L, et al.
Cell
. 2018 Apr;
173(4):1003-1013.e15.
PMID: 29681457
The majority of newly diagnosed prostate cancers are slow growing, with a long natural life history. Yet a subset can metastasize with lethal consequences. We reconstructed the phylogenies of 293...
7.
Fraser M, Sabelnykova V, Yamaguchi T, Heisler L, Livingstone J, Huang V, et al.
Nature
. 2017 Jan;
541(7637):359-364.
PMID: 28068672
Prostate tumours are highly variable in their response to therapies, but clinically available prognostic factors can explain only a fraction of this heterogeneity. Here we analysed 200 whole-genome sequences and...
8.
Taylor R, Fraser M, Livingstone J, Espiritu S, Thorne H, Huang V, et al.
Nat Commun
. 2017 Jan;
8:13671.
PMID: 28067867
Germline mutations in the BRCA2 tumour suppressor are associated with both an increased lifetime risk of developing prostate cancer (PCa) and increased risk of aggressive disease. To understand this aggression,...