Seung-Shick Shin
Overview
Explore the profile of Seung-Shick Shin including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
694
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Recent Articles
21.
Wen Y, Li J, Koo J, Shin S, Lin Y, Jeong B, et al.
Cancer Res
. 2014 Feb;
74(9):2499-509.
PMID: 24491800
Glutamate-triggered signal transduction is thought to contribute widely to cancer pathogenesis. In melanoma, overexpression of the metabotropic glutamate receptor (GRM)-1 occurs frequently and its ectopic expression in melanocytes is sufficient...
22.
Lee H, Wall B, Wangari-Talbot J, Shin S, Rosenberg S, Chan J, et al.
Clin Cancer Res
. 2011 Aug;
17(22):7080-92.
PMID: 21844014
Purpose: Melanoma is a heterogeneous disease where monotherapies are likely to fail due to variations in genomic signatures. B-RAF inhibitors have been clinically inadequate but response might be augmented with...
23.
Shin S, Wall B, Goydos J, Chen S
Pigment Cell Melanoma Res
. 2009 Oct;
23(1):103-11.
PMID: 19843246
We reported earlier on the oncogenic properties of Grm1 by demonstrating that stable Grm1-mouse-melanocytic clones proliferate in the absence of growth supplement and anchorage in vitro. In addition, these clones...
24.
Shin S, Martino J, Chen S
Neuropharmacology
. 2008 Jun;
55(4):396-402.
PMID: 18554669
Although the glutamatergic system usually functions in the CNS, expression has been observed in non-neuronal tissues and a subset of cancers. Metabotropic glutamate receptors (mGlus) are highly "druggable" GPCRs and...
25.
Shin S, Namkoong J, Wall B, Gleason R, Lee H, Chen S
Pigment Cell Melanoma Res
. 2008 Apr;
21(3):368-78.
PMID: 18435704
Previously, we reported a transgenic mouse line, TG-3, that develops spontaneous melanoma with 100% penetrance. We demonstrated that ectopic expression of Grm1 in melanocytes was sufficient to induce melanoma in...
26.
Namkoong J, Shin S, Lee H, Marin Y, Wall B, Goydos J, et al.
Cancer Res
. 2007 Mar;
67(5):2298-305.
PMID: 17332361
Recently, several laboratories have started to investigate the involvement of glutamate signaling in cancer. In previous studies, we reported on a transgenic mouse model that develops melanoma spontaneously. Subsequent studies...
27.
Marin Y, Namkoong J, Cohen-Solal K, Shin S, Martino J, Oka M, et al.
Cell Signal
. 2005 Nov;
18(8):1279-86.
PMID: 16305822
Metabotropic glutamate receptor 1 (Grm1, formerly mGluR1) is a G protein coupled receptor (GPCR) normally expressed and functional in the central nervous system. Studies of our transgenic mouse melanoma model...
28.
Marin Y, Namkoong J, Shin S, Raines J, Degenhardt K, White E, et al.
Neuropharmacology
. 2005 Jul;
49 Suppl 1:70-9.
PMID: 16040064
Melanoma is the aberrant proliferation of melanocytes, the cells in the skin responsible for pigment (melanin) production. In its early stages, melanoma can be surgically removed with great success, however,...
29.
Pollock P, Cohen-Solal K, Sood R, Namkoong J, Martino J, Koganti A, et al.
Nat Genet
. 2003 Apr;
34(1):108-12.
PMID: 12704387
To gain insight into melanoma pathogenesis, we characterized an insertional mouse mutant, TG3, that is predisposed to develop multiple melanomas. Physical mapping identified multiple tandem insertions of the transgene into...