Setu M Vora
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Explore the profile of Setu M Vora including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
963
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Recent Articles
1.
Fontana P, Du G, Zhang Y, Zhang H, Vora S, Hu J, et al.
Cell
. 2024 Sep;
187(22):6165-6181.e22.
PMID: 39243763
Gasdermin-mediated inflammatory cell death (pyroptosis) can activate protective immunity in immunologically cold tumors. Here, we performed a high-throughput screen for compounds that could activate gasdermin D (GSDMD), which is expressed...
2.
Junqueira C, Crespo A, Ranjbar S, de Lacerda L, Lewandrowski M, Ingber J, et al.
Nature
. 2022 Apr;
606(7914):576-584.
PMID: 35385861
SARS-CoV-2 can cause acute respiratory distress and death in some patients. Although severe COVID-19 is linked to substantial inflammation, how SARS-CoV-2 triggers inflammation is not clear. Monocytes and macrophages are...
3.
Vora S, Fontana P, Mao T, Leger V, Zhang Y, Fu T, et al.
Proc Natl Acad Sci U S A
. 2022 Feb;
119(9).
PMID: 35149555
SARS-CoV-2 is a highly pathogenic virus that evades antiviral immunity by interfering with host protein synthesis, mRNA stability, and protein trafficking. The SARS-CoV-2 nonstructural protein 1 (Nsp1) uses its C-terminal...
4.
Huang Y, Yong P, Dickey D, Vora S, Wu H, Bernlohr D
Endocrinology
. 2022 Feb;
163(4).
PMID: 35136993
Obesity-linked diabetes is associated with accumulation of proinflammatory macrophages into adipose tissue leading to inflammasome activation and pyroptotic secretion of interleukin (IL)-1β and IL-18. Targeting fatty acid binding protein 4...
5.
Shen C, Li R, Negro R, Cheng J, Vora S, Fu T, et al.
Cell
. 2021 Oct;
184(23):5759-5774.e20.
PMID: 34678144
NLRP6 is important in host defense by inducing functional outcomes including inflammasome activation and interferon production. Here, we show that NLRP6 undergoes liquid-liquid phase separation (LLPS) upon interaction with double-stranded...
6.
Junqueira C, Crespo A, Ranjbar S, Lewandrowski M, Ingber J, de Lacerda L, et al.
Res Sq
. 2021 Aug;
PMID: 34401873
SARS-CoV-2 causes acute respiratory distress that can progress to multiorgan failure and death in a minority of patients. Although severe COVID-19 disease is linked to exuberant inflammation, how SARS-CoV-2 triggers...
7.
Vora S, Lieberman J, Wu H
Nat Rev Immunol
. 2021 Aug;
21(11):694-703.
PMID: 34373622
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), results in life-threatening disease in a minority of patients, especially elderly people and those with co-morbidities such as...
8.
Wang L, Sharif H, Vora S, Zheng Y, Wu H
J Allergy Clin Immunol
. 2021 Jun;
147(6):2021-2029.
PMID: 34092352
Inflammasomes are molecular machines that carry out inflammatory responses on challenges by pathogens and endogenous dangers. Dysregulation of inflammasome assembly and regulation is associated with numerous human diseases from autoimmunity...
9.
Xia S, Zhang Z, Magupalli V, Pablo J, Dong Y, Vora S, et al.
Nature
. 2021 Apr;
593(7860):607-611.
PMID: 33883744
As organelles of the innate immune system, inflammasomes activate caspase-1 and other inflammatory caspases that cleave gasdermin D (GSDMD). Caspase-1 also cleaves inactive precursors of the interleukin (IL)-1 family to...
10.
Junqueira C, Crespo A, Ranjbar S, Ingber J, Parry B, Ravid S, et al.
medRxiv
. 2021 Mar;
PMID: 33758872
One Sentence Summary: Antibody-mediated SARS-CoV-2 infection of monocytes activates inflammation and cytokine release.