Tian-Min Fu
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Explore the profile of Tian-Min Fu including associated specialties, affiliations and a list of published articles.
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47
Citations
1680
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Recent Articles
1.
Rish A, Fosuah E, Shen Z, Marathe I, Wysocki V, Fu T
Mol Cell
. 2025 Feb;
PMID: 40010344
Leveraging AlphaFold models and integrated experiments, we characterized the HerA-DUF4297 (DUF) anti-phage defense system, focusing on DUF's undefined biochemical functions. Guided by structure-based genomic analyses, we found DUF homologs to...
2.
Rish A, Fosuah E, Shen Z, Marathe I, Wysocki V, Fu T
bioRxiv
. 2024 Nov;
PMID: 39484427
Leveraging the rich structural information provided by AlphaFold, we used integrated experimental approaches to characterize the HerA-DUF4297 (DUF) anti-phage defense system, in which DUF is of unknown function. To infer...
3.
Wang C, Shen Z, Yang X, Fu T
RNA Biol
. 2024 Sep;
21(1):1-7.
PMID: 39219231
Argonaute proteins (Agos) represent a highly conserved family of proteins prevalent in all domains of life and have been implicated in various biological processes. Based on the domain architecture, Agos...
4.
Yang X, Shen Z, Wang C, Nakanishi K, Fu T
Cell
. 2024 Aug;
187(19):5253-5266.e16.
PMID: 39173632
Horizontal gene transfer is a key driver of bacterial evolution, but it also presents severe risks to bacteria by introducing invasive mobile genetic elements. To counter these threats, bacteria have...
5.
Yang X, Shen Z, Wang C, Nakanishi K, Fu T
bioRxiv
. 2024 Jul;
PMID: 39071313
Horizontal gene transfer is a key driver of bacterial evolution, but it also presents severe risks to bacteria by introducing invasive mobile genetic elements. To counter these threats, bacteria have...
6.
Yang X, Shen Z, Xie J, Greenwald J, Marathe I, Lin Q, et al.
Nat Struct Mol Biol
. 2024 Apr;
31(8):1243-1250.
PMID: 38627580
As one of the most prevalent anti-phage defense systems in prokaryotes, Gabija consists of a Gabija protein A (GajA) and a Gabija protein B (GajB). The assembly and function of...
7.
Li Y, Shen Z, Zhang M, Yang X, Cleary S, Xie J, et al.
Nat Struct Mol Biol
. 2024 Jan;
31(3):413-423.
PMID: 38177683
Escherichia coli Septu system, an anti-phage defense system, comprises two components: PtuA and PtuB. PtuA contains an ATPase domain, while PtuB is predicted to function as a nuclease. Here we...
8.
Shen Z, Lin Q, Yang X, Fosuah E, Fu T
Mol Cell
. 2023 Dec;
83(24):4586-4599.e5.
PMID: 38096827
SIR2-HerA, a bacterial two-protein anti-phage defense system, induces bacterial death by depleting NAD upon phage infection. Biochemical reconstitution of SIR2, HerA, and the SIR2-HerA complex reveals a dynamic assembly process....
9.
Solebo O, Ling L, Nwankwo I, Zhou J, Fu T, Ke H
PLoS Pathog
. 2023 Dec;
19(12):e1011818.
PMID: 38048362
During asexual growth and replication cycles inside red blood cells, the malaria parasite Plasmodium falciparum primarily relies on glycolysis for energy supply, as its single mitochondrion performs little or no...
10.
Zheng W, Rawson S, Shen Z, Tamilselvan E, Smith H, Halford J, et al.
Neuron
. 2023 Aug;
111(20):3195-3210.e7.
PMID: 37543036
OSCA/TMEM63s form mechanically activated (MA) ion channels in plants and animals, respectively. OSCAs and related TMEM16s and transmembrane channel-like (TMC) proteins form homodimers with two pores. Here, we uncover an...