Seth Winfree
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Explore the profile of Seth Winfree including associated specialties, affiliations and a list of published articles.
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60
Citations
1606
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Recent Articles
1.
Chen A, Han S, Lee S, Fu C, Yang C, Wu L, et al.
J Med Imaging (Bellingham)
. 2025 Mar;
12(2):024001.
PMID: 40078780
Purpose: The advancement of high-content optical microscopy has enabled the acquisition of very large three-dimensional (3D) image datasets. The analysis of these image volumes requires more computational resources than a...
2.
McCaffrey E, Delmastro A, Fitzhugh I, Ranek J, Douglas S, Peters J, et al.
bioRxiv
. 2025 Mar;
PMID: 40027668
Despite being heavily infiltrated by immune cells, tuberculosis (TB) granulomas often subvert the host response to (Mtb) infection and support bacterial persistence. We previously discovered that human TB granulomas are...
3.
Ferreira R, Gisch D, Phillips C, Cheng Y, Asthana M, Lake B, et al.
bioRxiv
. 2025 Jan;
PMID: 39803522
The maintenance of a healthy epithelial-endothelial juxtaposition requires cross-talk within glomerular cellular niches. We sought to understand the spatially-anchored regulation and transition of endothelial and mesangial cells from health to...
4.
Asghari M, Sabo A, Barwinska D, Ferreira R, Ferkowicz M, Bowen W, et al.
bioRxiv
. 2024 Dec;
PMID: 39677736
The organizational principles of nephronal segments are based on longstanding anatomical and physiological attributes that are closely linked to the homeostatic functions of the kidney. Novel molecular approaches have recently...
5.
Ghajar-Rahimi G, Barwinska D, Whipple G, Kamocka M, Khan S, Winfree S, et al.
Am J Physiol Renal Physiol
. 2024 Sep;
327(5):F869-F884.
PMID: 39323387
The long-term effects of a single episode of acute kidney injury (AKI) induced by bilateral ischemia-reperfusion injury (BIRI) on kidney lymphatic dynamics are not known. The purpose of this study...
6.
Kolb A, Corridon P, Ullah M, Pfaffenberger Z, Xu W, Winfree S, et al.
Biochemistry
. 2024 Aug;
63(18):2310-2322.
PMID: 39194960
Hypothesis: In this communication, we test the hypothesis that sulfotransferase 1C2 (SULT1C2, UniProt accession no. Q9WUW8) can modulate mitochondrial respiration by increasing state-III respiration. Methods And Results: Using freshly isolated...
7.
Gisch D, Brennan M, Lake B, Basta J, Keller M, Ferreira R, et al.
Nat Commun
. 2024 Jan;
15(1):433.
PMID: 38199997
There is a need to define regions of gene activation or repression that control human kidney cells in states of health, injury, and repair to understand the molecular pathogenesis of...
8.
Dailey K, Small J, Pullan J, Winfree S, Vance K, Orr M, et al.
PLoS One
. 2023 Nov;
18(11):e0289183.
PMID: 37963142
Clostridium novyi has demonstrated selective efficacy against solid tumors largely due to the microenvironment contained within dense tumor cores. The core of a solid tumor is typically hypoxic, acidic, and...
9.
Mikosz A, Ni K, Gally F, Pratte K, Winfree S, Lin Q, et al.
Am J Physiol Lung Cell Mol Physiol
. 2023 Oct;
325(6):L711-L725.
PMID: 37814796
Chronic obstructive pulmonary disease (COPD) is characterized by nonresolving inflammation fueled by breach in the endothelial barrier and leukocyte recruitment into the airspaces. Among the ligand-receptor axes that control leukocyte...
10.
Lake B, Menon R, Winfree S, Hu Q, Ferreira R, Kalhor K, et al.
Nature
. 2023 Jul;
619(7970):585-594.
PMID: 37468583
Understanding kidney disease relies on defining the complexity of cell types and states, their associated molecular profiles and interactions within tissue neighbourhoods. Here we applied multiple single-cell and single-nucleus assays...