Sergey V Melnikov
Overview
Explore the profile of Sergey V Melnikov including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
419
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0
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Recent Articles
1.
Ekemezie C, Melnikov S
Front Microbiol
. 2024 Aug;
15:1436579.
PMID: 39135874
When ribosome-targeting antibiotics attack actively growing bacteria, they occupy ribosomal active centers, causing the ribosomes to stall or make errors that either halt cellular growth or cause bacterial death. However,...
2.
Helena-Bueno K, Chan L, Melnikov S
Front Microbiol
. 2024 May;
15:1386179.
PMID: 38770025
Throughout the tree of life, cells and organisms enter states of dormancy or hibernation as a key feature of their biology: from a bacterium arresting its growth in response to...
3.
Thaenert A, Sevostyanova A, Chung C, Vargas-Rodriguez O, Melnikov S, Soll D
Proc Natl Acad Sci U S A
. 2024 Mar;
121(11):e2321700121.
PMID: 38442159
Ribosomes are often used in synthetic biology as a tool to produce desired proteins with enhanced properties or entirely new functions. However, repurposing ribosomes for producing designer proteins is challenging...
4.
Helena-Bueno K, Rybak M, Ekemezie C, Sullivan R, Brown C, Dingwall C, et al.
Nature
. 2024 Feb;
626(8001):1125-1132.
PMID: 38355796
To conserve energy during starvation and stress, many organisms use hibernation factor proteins to inhibit protein synthesis and protect their ribosomes from damage. In bacteria, two families of hibernation factors...
5.
Krahn N, Zhang J, Melnikov S, Tharp J, Villa A, Patel A, et al.
Nucleic Acids Res
. 2023 Dec;
52(2):513-524.
PMID: 38100361
Protein translation is orchestrated through tRNA aminoacylation and ribosomal elongation. Among the highly conserved structure of tRNAs, they have distinguishing features which promote interaction with their cognate aminoacyl tRNA synthetase...
6.
Schierholz L, Brown C, Helena-Bueno K, Uversky V, Hirt R, Barandun J, et al.
Mol Biol Evol
. 2023 Nov;
41(1).
PMID: 37987564
Ribosomes from different species can markedly differ in their composition by including dozens of ribosomal proteins that are unique to specific lineages but absent in others. However, it remains unknown...
7.
van den Elzen A, Helena-Bueno K, Brown C, Chan L, Melnikov S
Nucleic Acids Res
. 2023 Jul;
51(15):8048-8059.
PMID: 37395434
Ribosomal genes are widely used as 'molecular clocks' to infer evolutionary relationships between species. However, their utility as 'molecular thermometers' for estimating optimal growth temperature of microorganisms remains uncertain. Previously,...
8.
Nicholson D, Salamina M, Panek J, Helena-Bueno K, Brown C, Hirt R, et al.
Nat Commun
. 2022 Feb;
13(1):591.
PMID: 35105900
The evolution of microbial parasites involves the counterplay between natural selection forcing parasites to improve and genetic drifts forcing parasites to lose genes and accumulate deleterious mutations. Here, to understand...
9.
Melnikov S, Stevens D, Fu X, Kwok H, Zhang J, Shen Y, et al.
Proc Natl Acad Sci U S A
. 2020 Jul;
117(30):17924-17931.
PMID: 32661175
Antibiotic resistance frequently evolves through fitness trade-offs in which the genetic alterations that confer resistance to a drug can also cause growth defects in resistant cells. Here, through experimental evolution...
10.
Melnikov S, Soll D
Int J Mol Sci
. 2019 Apr;
20(8).
PMID: 31010123
In the past two decades, tRNA molecules and their corresponding aminoacyl-tRNA synthetases (aaRS) have been extensively used in synthetic biology to genetically encode post-translationally modified and unnatural amino acids. In...