Yury S Polikanov
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Explore the profile of Yury S Polikanov including associated specialties, affiliations and a list of published articles.
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68
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2079
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Recent Articles
1.
Tresco B, Wu K, Ramkissoon A, Aleksandrova E, Purdy M, See D, et al.
Nat Chem
. 2025 Mar;
PMID: 40055575
The emergence of bacterial antimicrobial resistance threatens to undermine the utility of antibiotic therapy in medicine. This threat can be addressed, in part, by reinventing existing antibiotic classes using chemical...
2.
Rahman A, Syroegin E, Novomisky Nechcoff J, Devarajan A, Polikanov Y, Cardona S
Cell Rep
. 2024 Nov;
43(11):114967.
PMID: 39541213
Bacterial mutant libraries with downregulated antibiotic targets are useful tools for elucidating the mechanisms of action of antibacterial compounds, a pivotal step in antibiotic discovery. However, achieving genomic coverage of...
3.
Kurata T, Takegawa M, Ohira T, Syroegin E, Atkinson G, Johansson M, et al.
Sci Adv
. 2024 Nov;
10(46):eadr9624.
PMID: 39536105
Translation-targeting toxic small alarmone synthetases (toxSAS) are effectors of bacterial toxin-antitoxin systems that pyrophosphorylate the 3'-CCA end of transfer RNA (tRNA) to prevent aminoacylation. toxSAS are implicated in antiphage immunity:...
4.
Huang W, Baliga C, Aleksandrova E, Atkinson G, Polikanov Y, Vazquez-Laslop N, et al.
EMBO Rep
. 2024 Oct;
25(11):5194-5211.
PMID: 39415050
Apidaecin 1b (Api), the first characterized Type II Proline-rich antimicrobial peptide (PrAMP), is encoded in the honey bee genome. It inhibits bacterial growth by binding in the nascent peptide exit...
5.
Jones J, Franco M, Giles R, Eyler D, Tardu M, Smith T, et al.
Proc Natl Acad Sci U S A
. 2024 Aug;
121(35):e2401743121.
PMID: 39159370
While the centrality of posttranscriptional modifications to RNA biology has long been acknowledged, the function of the vast majority of modified sites remains to be discovered. Illustrative of this, there...
6.
Aleksandrova E, Ma C, Klepacki D, Alizadeh F, Vazquez-Laslop N, Liang J, et al.
Nat Chem Biol
. 2024 Jul;
20(12):1680-1690.
PMID: 39039256
Growing resistance toward ribosome-targeting macrolide antibiotics has limited their clinical utility and urged the search for superior compounds. Macrolones are synthetic macrolide derivatives with a quinolone side chain, structurally similar...
7.
Batool Z, Pavlova J, Paranjpe M, Tereshchenkov A, Lukianov D, Osterman I, et al.
Structure
. 2024 Jul;
32(9):1429-1442.e6.
PMID: 39019034
Chloramphenicol (CHL) is an antibiotic targeting the peptidyl transferase center in bacterial ribosomes. We synthesized a new analog, CAM-BER, by substituting the dichloroacetyl moiety of CHL with a positively charged...
8.
Kurata T, Takegawa M, Ohira T, Syroegin E, Atkinson G, Johansson M, et al.
bioRxiv
. 2024 Jul;
PMID: 39005314
Translation-targeting toxic Small Alarmone Synthetases (toxSAS) are effectors of bacterial Toxin-Antitoxin systems that pyrophosphorylate the 3'-CCA end of tRNA to prevent aminoacylation. toxSAS are implicated in antiphage immunity: phage detection...
9.
Rahman A, Syroegin E, Novomisky Nechcoff J, Devarajan A, Polikanov Y, Cardona S
bioRxiv
. 2024 Jul;
PMID: 38979387
Summary: Bacterial mutant libraries in which antibiotic targets are downregulated are useful tools to functionally characterize novel antimicrobials. These libraries are used for chemical-genetic profiling as target-compound interactions can be...
10.
Wu K, Tresco B, Ramkissoon A, Aleksandrova E, Syroegin E, See D, et al.
Science
. 2024 Feb;
383(6684):721-726.
PMID: 38359125
We report the design conception, chemical synthesis, and microbiological evaluation of the bridged macrobicyclic antibiotic cresomycin (CRM), which overcomes evolutionarily diverse forms of antimicrobial resistance that render modern antibiotics ineffective....