Sergey N Krylov
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Explore the profile of Sergey N Krylov including associated specialties, affiliations and a list of published articles.
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162
Citations
1380
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Recent Articles
21.
Kochmann S, Ivanov N, Lucas K, Krylov S
Anal Chem
. 2021 Jul;
93(29):9980-9985.
PMID: 34255479
In molecular-stream separation (MSS), a stream of a multicomponent mixture is separated into multiple streams of individual components. Quantitative evaluation of MSS data has been a bottleneck in MSS for...
22.
Le A, Krylova S, Beloborodov S, Wang T, Hili R, Johnson P, et al.
Anal Chem
. 2021 Mar;
93(13):5343-5354.
PMID: 33764056
Screening molecular libraries for ligands capable of binding proteins is widely used for hit identification in the early drug discovery process. Oligonucleotide libraries provide a very high diversity of compounds,...
23.
Hu L, Krylova S, Liu S, Yousef G, Krylov S
Anal Chem
. 2020 Oct;
92(20):14251-14258.
PMID: 33006882
Thousands of putative microRNA (miRNA)-based cancer biomarkers have been reported, but none has been validated for approval by the Food and Drug Administration. One of the reasons for this alarming...
24.
De Oliveira M, Koshkin V, Liu G, Krylov S
Anal Chem
. 2020 Aug;
92(18):12101-12110.
PMID: 32790291
Chemoresistance, i.e., tumor insensitivity to chemotherapy, shortens life expectancy of cancer patients. Despite the availability of new treatment options, initial systemic regimens for solid tumors are dominated by a set...
25.
Rukundo J, Le Blanc J, Kochmann S, Krylov S
Anal Chem
. 2020 Aug;
92(17):11973-11980.
PMID: 32786479
Analytical methods may not have reference standards required for testing their accuracy. We postulate that the accuracy of an analytical method can be assessed in the absence of reference standards...
26.
Koshkin V, De Oliveira M, Peng C, Ailles L, Liu G, Covens A, et al.
Anal Chem
. 2020 Jun;
92(13):9348-9355.
PMID: 32522000
Cytometry of Reaction Rate Constant (CRRC) uses time-lapse fluorescence microscopy to measure a rate constant of a catalytic reaction in individual cells and, thus, facilitate accurate size determination for cell...
27.
Wang T, Hu L, Krylov S
Electrophoresis
. 2020 Apr;
41(13-14):1225-1229.
PMID: 32310305
Ideal-filter CE (IFCE) is a method for the selection of affinity binders for protein targets from oligonucleotide libraries, for example, random-sequence oligonucleotide libraries and DNA-encoded libraries, in a single step...
28.
Ivanov N, Kochmann S, Krylov S
Anal Chem
. 2020 Jan;
92(4):2907-2910.
PMID: 31986876
Continuous-flow electrophoresis (CFE) separates a stream of a multicomponent mixture into multiple streams of individual components inside a thin rectangular chamber. CFE will be able to benefit flow chemistry when...
29.
Beloborodov S, Krylova S, Krylov S
Anal Chem
. 2019 Sep;
91(20):12680-12687.
PMID: 31525943
DNA aptamers are single-strand DNA (ssDNA) capable of selectively and tightly binding a target molecule. Capillary electrophoresis-based selection of aptamers for protein targets requires the knowledge of electrophoretic mobilities of...
30.
Ivanov N, Liu Y, Kochmann S, Krylov S
Lab Chip
. 2019 Jun;
19(13):2156-2160.
PMID: 31161184
We introduce non-aqueous continuous-flow electrophoresis (NACFE) in which the electrolyte is a solution of an organic salt in an aprotic organic solvent. NACFE can maintain steady-state separation of multiple hydrophobic...