Sergey G Koshelev
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Explore the profile of Sergey G Koshelev including associated specialties, affiliations and a list of published articles.
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21
Citations
261
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Recent Articles
1.
Khasanov T, Maleeva E, Koshelev S, Palikov V, Palikova Y, Dyachenko I, et al.
Mar Drugs
. 2024 Sep;
22(9).
PMID: 39330263
Acid-sensing ion channels (ASICs), which act as proton-gating sodium channels, have garnered attention as pharmacological targets. ASIC1a isoform, notably prevalent in the central nervous system, plays an important role in...
2.
Osmakov D, Onoprienko L, Kalinovskii A, Koshelev S, Stepanenko V, Andreev Y, et al.
Int J Mol Sci
. 2024 Feb;
25(3).
PMID: 38338690
Tafalgin (Taf) is a tetrapeptide opioid used in clinical practice in Russia as an analgesic drug for subcutaneous administration as a solution (4 mg/mL; concentration of 9 mM). We found...
3.
Gladkikh I, Klimovich A, Kalina R, Kozhevnikova Y, Khasanov T, Osmakov D, et al.
Toxins (Basel)
. 2023 May;
15(5).
PMID: 37235375
Acid-sensing ion channels (ASICs) have been known as sensors of a local pH change within both physiological and pathological conditions. ASIC-targeting peptide toxins could be potent molecular tools for ASIC-manipulating...
4.
Kalina R, Gladkikh I, Klimovich A, Kozhevnikova Y, Kvetkina A, Rogozhin E, et al.
Biomolecules
. 2022 Nov;
12(11).
PMID: 36421718
A novel peptide AnmTX Sco 9a-1 with the β-hairpin fold was isolated from the swimming sea anemone (Actinostolidae family). The peptide consists of 28 amino acid residues, including modified hydroxyproline...
5.
Kalina R, Kasheverov I, Koshelev S, Sintsova O, Peigneur S, Pinheiro-Junior E, et al.
Toxins (Basel)
. 2022 Oct;
14(10).
PMID: 36287966
The nicotinic acetylcholine receptors (nAChRs) are prototypical ligand-gated ion channels, provide cholinergic signaling, and are modulated by various venom toxins and drugs in addition to neurotransmitters. Here, four APETx-like toxins,...
6.
Sudarikova A, Bychkov M, Kulbatskii D, Chubinskiy-Nadezhdin V, Shlepova O, Shulepko M, et al.
Front Oncol
. 2022 Jul;
12:904742.
PMID: 35837090
Lung cancer is one of the most common cancer types in the world. Despite existing treatment strategies, overall patient survival remains low and new targeted therapies are required. Acidification of...
7.
Kalinovskii A, Osmakov D, Koshelev S, Lubova K, Korolkova Y, Kozlov S, et al.
Biology (Basel)
. 2022 Feb;
11(2).
PMID: 35205034
Human neuroblastoma SH-SY5Y is a prominent neurobiological tool used for studying neuropathophysiological processes. We investigated acid-sensing (ASIC) and transient receptor potential vanilloid-1 (TRPV1) and ankyrin-1 (TRPA1) ion channels present in...
8.
Bychkov M, Shulepko M, Shlepova O, Kulbatskii D, Chulina I, Paramonov A, et al.
Front Cell Dev Biol
. 2021 Oct;
9:739391.
PMID: 34595181
Secreted Ly6/uPAR-related protein 1 (SLURP-1) is a secreted Ly6/uPAR protein that negatively modulates the nicotinic acetylcholine receptor of α7 type (α7-nAChR), participating in control of cancer cell growth. Previously we...
9.
Belozerova O, Osmakov D, Vladimirov A, Koshelev S, Chugunov A, Andreev Y, et al.
Pharmaceuticals (Basel)
. 2020 Jul;
13(8).
PMID: 32722325
Among acid-sensing ion channels (ASICs), ASIC1a and ASIC3 subunits are the most widespread and prevalent in physiological and pathophysiological conditions. They participate in synaptic plasticity, learning and memory, as well...
10.
Kalina R, Koshelev S, Zelepuga E, Kim N, Kozlov S, Kozlovskaya E, et al.
Toxins (Basel)
. 2020 Apr;
12(4).
PMID: 32326130
Currently, five peptide modulators of acid-sensing ion channels (ASICs) attributed to structural class 1b of sea anemone toxins have been described. The APETx2 toxin is the first and most potent...