Serenella Deplano
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Explore the profile of Serenella Deplano including associated specialties, affiliations and a list of published articles.
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8
Citations
58
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Recent Articles
1.
Di Maria S, Picarazzi F, Mori M, Cianciusi A, Carbone A, Crespan E, et al.
Bioorg Chem
. 2022 Aug;
128:106071.
PMID: 35932498
The Bcr-Abl tyrosine kinase (TK) is the molecular hallmark of chronic myeloid leukemia (CML). Src is another TK kinase whose involvement in CML was widely demonstrated. Small molecules active as...
2.
Meleddu R, Corona A, Distinto S, Cottiglia F, Deplano S, Sequeira L, et al.
Molecules
. 2021 Jul;
26(13).
PMID: 34201561
Current therapeutic protocols for the treatment of HIV infection consist of the combination of diverse anti-retroviral drugs in order to reduce the selection of resistant mutants and to allow for...
3.
Meleddu R, Deplano S, Maccioni E, Ortuso F, Cottiglia F, Secci D, et al.
J Enzyme Inhib Med Chem
. 2021 Feb;
36(1):685-692.
PMID: 33602041
A small library of coumarin and their psoralen analogues and has been designed and synthesised to investigate the effect of structural modifications on their inhibition ability and selectivity profile towards...
4.
Meleddu R, Distinto S, Cottiglia F, Angius R, Caboni P, Angeli A, et al.
ACS Med Chem Lett
. 2020 May;
11(5):852-856.
PMID: 32435395
In the present study we investigated the structure-activity relationships of a new series of 4-[(3-ethyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzene-1-sulfonamides (-). All synthesized compounds, with the exception of compound , preferentially inhibit off-target hCA II...
5.
Fois B, Distinto S, Meleddu R, Deplano S, Maccioni E, Floris C, et al.
J Enzyme Inhib Med Chem
. 2020 Jan;
35(1):539-548.
PMID: 31948300
In an screening for human carbonic anhydrase (hCA) inhibiting agents from higher plants, the petroleum ether and ethyl acetate extracts of seeds selectively inhibited hCA IX and hCA XII isoforms....
6.
Distinto S, Meleddu R, Ortuso F, Cottiglia F, Deplano S, Sequeira L, et al.
J Enzyme Inhib Med Chem
. 2019 Aug;
34(1):1526-1533.
PMID: 31431095
A library of 4-[(3-methyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzene-1-sulphonamides () was designed and synthesised to evaluate the effect of substituents in the positions 3 and 4 of the dihydrothiazole ring on the inhibitory potency and...
7.
Meleddu R, Petrikaite V, Distinto S, Arridu A, Angius R, Serusi L, et al.
ACS Med Chem Lett
. 2019 Apr;
10(4):571-576.
PMID: 30996798
A series of isatin-dihydropyrazole hybrids have been synthesized in order to assess their potential as anticancer agents. In particular, 12 compounds were evaluated for their antiproliferative activity toward A549, IGR39,...
8.
Meleddu R, Distinto S, Cottiglia F, Angius R, Gaspari M, Taverna D, et al.
ACS Med Chem Lett
. 2018 Oct;
9(10):1045-1050.
PMID: 30344915
A novel series of of 4-[(3-phenyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzene-1-sulfonamides () was synthesized and assayed toward both human carbonic anhydrase isozymes I, II, IX, and XII and cyclooxygenase isoforms. The majority of these derivatives...