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Serena Chang

Explore the profile of Serena Chang including associated specialties, affiliations and a list of published articles. Areas
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Articles 16
Citations 580
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Recent Articles
1.
Chan D, Heng T, Zheng R, Chang S, Loy S, Ku C, et al.
BMC Med Educ . 2024 Oct; 24(1):1097. PMID: 39375655
Background: To mitigate the growing burden of non-communicable diseases, doctors training to become paediatricians should be equipped with concepts and knowledge regarding Developmental Origins of Health and Disease (DOHaD). Methods:...
2.
Brennan K, Espin-Perez A, Chang S, Bedi N, Saumyaa S, Shin J, et al.
Genome Med . 2023 Nov; 15(1):98. PMID: 37978395
Background: The prognosis for patients with head and neck cancer (HNC) is poor and has improved little in recent decades, partially due to lack of therapeutic options. To identify effective...
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Wu E, Trevino A, Wu Z, Swanson K, Kim H, DAngio H, et al.
PNAS Nexus . 2023 Jun; 2(6):pgad171. PMID: 37275261
Multiplex immunofluorescence (mIF) assays multiple protein biomarkers on a single tissue section. Recently, high-plex CODEX (co-detection by indexing) systems enable simultaneous imaging of 40+ protein biomarkers, unlocking more detailed molecular...
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Zhang W, Li I, Reticker-Flynn N, Good Z, Chang S, Samusik N, et al.
Nat Methods . 2022 Jun; 19(6):759-769. PMID: 35654951
Advances in multiplexed in situ imaging are revealing important insights in spatial biology. However, cell type identification remains a major challenge in imaging analysis, with most existing methods involving substantial...
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Reticker-Flynn N, Zhang W, Belk J, Basto P, Escalante N, Pilarowski G, et al.
Cell . 2022 May; 185(11):1924-1942.e23. PMID: 35525247
For many solid malignancies, lymph node (LN) involvement represents a harbinger of distant metastatic disease and, therefore, an important prognostic factor. Beyond its utility as a biomarker, whether and how...
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Moreno-Nieves U, Tay J, Saumyaa S, Horowitz N, Shin J, Mohammad I, et al.
Proc Natl Acad Sci U S A . 2021 Jul; 118(28). PMID: 34244432
Natural killer (NK) cells comprise one subset of the innate lymphoid cell (ILC) family. Despite reported antitumor functions of NK cells, their tangible contribution to tumor control in humans remains...
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Nair N, Chen S, Lemmens E, Chang S, Le D, Jaffee E, et al.
Cancer Immunol Res . 2020 Mar; 8(5):609-617. PMID: 32132105
The identification of biomarkers for patient stratification is fundamental to precision medicine efforts in oncology. Here, we identified two baseline, circulating immune cell subsets associated with overall survival in patients...
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Crosby E, Gwin W, Blackwell K, Marcom P, Chang S, Maecker H, et al.
Clin Cancer Res . 2019 Jan; 25(9):2725-2736. PMID: 30635338
Purpose: Immune-based therapy for metastatic breast cancer has had limited success, particularly in molecular subtypes with low somatic mutations rates. Strategies to augment T-cell infiltration of tumors include vaccines targeting...
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Chang S, Kohrt H, Maecker H
Cancer Immunol Immunother . 2014 Feb; 63(7):713-9. PMID: 24487923
A new era of cancer immunotherapy has brought not only successful cancer vaccines but also immunomodulators, such as those that target checkpoint blockade in order to induce endogenous host immune...