Serapion Pyrpassopoulos
Overview
Explore the profile of Serapion Pyrpassopoulos including associated specialties, affiliations and a list of published articles.
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19
Citations
228
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Recent Articles
1.
Pedersen R, Snoberger A, Pyrpassopoulos S, Safer D, Drubin D, Ostap E
J Cell Biol
. 2023 Aug;
222(10).
PMID: 37549220
Myosins are required for clathrin-mediated endocytosis, but their precise molecular roles in this process are not known. This is, in part, because the biophysical properties of the relevant motors have...
2.
Pedersen R, Snoberger A, Pyrpassopoulos S, Safer D, Drubin D, Ostap E
bioRxiv
. 2023 Mar;
PMID: 36993306
Summary: Pedersen, Snoberger et al. measure the force-sensitivity of the yeast endocytic the myosin-1 called Myo5 and find that it is more likely to generate power than to serve as...
3.
Pyrpassopoulos S, Gicking A, Zaniewski T, Hancock W, Ostap E
Proc Natl Acad Sci U S A
. 2023 Jan;
120(2):e2216903120.
PMID: 36598948
KIF1A is a highly processive vesicle transport motor in the kinesin-3 family. Mutations in KIF1A lead to neurodegenerative diseases including hereditary spastic paraplegia. We applied optical tweezers to study the...
4.
Pyrpassopoulos S, Shuman H, Ostap E
Biophys J
. 2022 Dec;
121(23):4748.
PMID: 36455557
No abstract available.
5.
Pyrpassopoulos S, Shuman H, Ostap E
Methods Mol Biol
. 2022 Sep;
2478:559-583.
PMID: 36063334
The cytoskeletal motors myosin, kinesin, and dynein and their corresponding tracks, actin and microtubules, are force generating ATPases responsible for motility and morphological changes at the intracellular, cellular, and tissue...
6.
Bensel B, Woody M, Pyrpassopoulos S, Goldman Y, Gilbert S, Ostap E
Proc Natl Acad Sci U S A
. 2020 Jun;
117(27):15632-15641.
PMID: 32571914
KIF3AC is a mammalian neuron-specific kinesin-2 implicated in intracellular cargo transport. It is a heterodimer of KIF3A and KIF3C motor polypeptides which have distinct biochemical and motile properties as engineered...
7.
Pyrpassopoulos S, Shuman H, Ostap E
Biophys J
. 2019 Dec;
118(1):243-253.
PMID: 31883614
Kinesin motors and their associated microtubule tracks are essential for long-distance transport of cellular cargos. Intracellular activity and proper recruitment of kinesins is regulated by biochemical signaling, cargo adaptors, microtubule-associated...
8.
McIntosh B, Pyrpassopoulos S, Holzbaur E, Ostap E
Curr Biol
. 2018 Jan;
28(2):236-248.e5.
PMID: 29337076
Microtubule and actin filament molecular motors such as kinesin-1 and myosin-Ic (Myo1c) transport and remodel membrane-bound vesicles; however, it is unclear how they coordinate to accomplish these tasks. We introduced...
9.
Pyrpassopoulos S, Shuman H, Ostap E
Mol Biol Cell
. 2017 Sep;
28(23):3315-3322.
PMID: 28931594
KIF16B is a highly processive kinesin-3 family member that participates in the trafficking and tubulation of early endosomes along microtubules. KIF16B attaches to lipid cargoes via a PX motif at...
10.
Pyrpassopoulos S, Arpag G, Feeser E, Shuman H, Tuzel E, Ostap E
Sci Rep
. 2016 May;
6:25524.
PMID: 27156719
Vertebrate myosin-IC (Myo1c) is a type-1 myosin that links cell membranes to the cytoskeleton via its actin-binding motor domain and its phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2)-binding tail domain. While it is known...