Daniel Safer
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Explore the profile of Daniel Safer including associated specialties, affiliations and a list of published articles.
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19
Citations
489
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Recent Articles
1.
Schiller H, Hong Y, Kouassi J, Rados T, Kwak J, DiLucido A, et al.
Nat Commun
. 2024 Feb;
15(1):1414.
PMID: 38360755
Archaea play indispensable roles in global biogeochemical cycles, yet many crucial cellular processes, including cell-shape determination, are poorly understood. Haloferax volcanii, a model haloarchaeon, forms rods and disks, depending on...
2.
Pedersen R, Snoberger A, Pyrpassopoulos S, Safer D, Drubin D, Ostap E
J Cell Biol
. 2023 Aug;
222(10).
PMID: 37549220
Myosins are required for clathrin-mediated endocytosis, but their precise molecular roles in this process are not known. This is, in part, because the biophysical properties of the relevant motors have...
3.
Pedersen R, Snoberger A, Pyrpassopoulos S, Safer D, Drubin D, Ostap E
bioRxiv
. 2023 Mar;
PMID: 36993306
Summary: Pedersen, Snoberger et al. measure the force-sensitivity of the yeast endocytic the myosin-1 called Myo5 and find that it is more likely to generate power than to serve as...
4.
Mukherjea M, Ali M, Kikuti C, Safer D, Yang Z, Sirkia H, et al.
Cell Rep
. 2014 Aug;
8(5):1522-32.
PMID: 25159143
It is unclear whether the reverse-direction myosin (myosin VI) functions as a monomer or dimer in cells and how it generates large movements on actin. We deleted a stable, single-α-helix...
5.
Hategan A, Gersh K, Safer D, Weisel J
Blood
. 2012 Dec;
121(8):1455-8.
PMID: 23233658
Individual fluorescently labeled fibrin(ogen) molecules and their assembly to make a clot were observed by total internal reflection fluorescence microscopy (TIRFM). We used the bleaching of the fluorescent labels to...
6.
Ali M, Kennedy G, Safer D, Trybus K, Sweeney H, Warshaw D
Proc Natl Acad Sci U S A
. 2011 Aug;
108(34):E535-41.
PMID: 21808051
Myosin Va (myoV) and myosin VI (myoVI) are processive molecular motors that transport cargo in opposite directions on actin tracks. Because these motors may bind to the same cargo in...
7.
Krieger C, Bhasin N, Tewari M, Brown A, Safer D, Sweeney H, et al.
Cytoskeleton (Hoboken)
. 2010 Oct;
67(12):796-807.
PMID: 20886611
Force-bearing linkages between the cytoskeleton and extracellular matrix are clearly important to normal cell viability-as is evident in a disease such as Duchenne muscular dystrophy (DMD) which arises in the...
8.
Phichith D, Travaglia M, Yang Z, Liu X, Zong A, Safer D, et al.
Proc Natl Acad Sci U S A
. 2009 Oct;
106(41):17320-4.
PMID: 19805065
Although myosin VI has properties that would allow it to function optimally as a dimer, full-length myosin VI exists as a monomer in isolation. Based on the ability of myosin...
9.
Mukherjea M, Llinas P, Kim H, Travaglia M, Safer D, Menetrey J, et al.
Mol Cell
. 2009 Aug;
35(3):305-15.
PMID: 19664948
Myosin VI challenges the prevailing theory of how myosin motors move on actin: the lever arm hypothesis. While the reverse directionality and large powerstroke of myosin VI can be attributed...
10.
Brown A, Hategan A, Safer D, Goldman Y, Discher D
Biophys J
. 2009 Mar;
96(5):1952-60.
PMID: 19254555
Myosin-II's rod-like tail drives filament assembly with a head arrangement that is often considered to be a symmetric bipole that generates equal and opposite contractile forces on actin. Self-assembled myosin...