Selim Cellek
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Explore the profile of Selim Cellek including associated specialties, affiliations and a list of published articles.
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46
Citations
557
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Recent Articles
1.
Ilg M, Lapthorn A, Harding S, Minhas T, Koduri G, Bustin S, et al.
Front Pharmacol
. 2025 Feb;
16:1526495.
PMID: 40017592
Background: In cancer metastasis, tumor cells condition distant tissues to create a supportive environment, or metastatic niche, by driving the activation of cancer-associated fibroblasts (CAFs). These CAFs remodel the extracellular...
2.
Inhibition of phosphodiesterases 1 and 4 prevents myofibroblast transformation in Peyronie's disease
Harding S, Ilg M, Bustin S, Ralph D, Cellek S
BJU Int
. 2024 Dec;
PMID: 39716367
Objectives: To investigate which phosphodiesterase (PDE) isoforms are expressed in fibroblasts isolated from the tunica albuginea (TA) of patients with Peyronie's disease (PD), and to measure the potency of PDE...
3.
Ilg M, Bustin S, Ralph D, Cellek S
Sci Rep
. 2024 May;
14(1):12389.
PMID: 38811625
Extracellular vesicles have emerged as important mediators of cell-to-cell communication in the pathophysiology of fibrotic diseases. One such disease is Peyronie's disease (PD), a fibrotic disorder of the penis caused...
4.
Ilg M, Harding S, Lapthorn A, Kirvell S, Ralph D, Bustin S, et al.
J Sex Med
. 2024 Feb;
21(4):278-287.
PMID: 38383071
Background: Transformation of resident fibroblasts to profibrotic myofibroblasts in the tunica albuginea is a critical step in the pathophysiology of Peyronie's disease (PD). We have previously shown that myofibroblasts do...
5.
Lapthorn A, Ilg M, Dziewulski P, Cellek S
Eur J Pharmacol
. 2024 Feb;
967:176369.
PMID: 38325796
Hypertrophic scars are a common complication of burn injuries, yet there are no medications to prevent their formation. During scar formation, resident fibroblasts are transformed to myofibroblasts which become resistant...
6.
Castiglione F, Cakir O, Schifano N, Corona G, Reisman Y, Bettocchi C, et al.
Sex Med
. 2023 Aug;
11(4):qfad046.
PMID: 37547872
Introduction: Animal models are frequently used for translational research in Peyronie's disease (PD). However, due to lack of availability of guidelines, there is some heterogeneity in study design, data reporting,...
7.
Cellek S, Megson M, Ilg M, Ralph D
J Sex Med
. 2023 Jul;
20(8):1057-1059.
PMID: 37524687
No abstract available.
8.
Ilg M, Ralph D, Cellek S
J Sex Med
. 2023 Apr;
20(7):925-934.
PMID: 37082866
Background: Peyronie's disease (PD) is a fibrotic disorder characterized by plaque formation in the tunica albuginea (TA) of the penis, and we have previously shown that inhibition of transformation of...
9.
Ilg M, Lapthorn A, Ralph D, Cellek S
PLoS One
. 2022 Dec;
17(12):e0277646.
PMID: 36508413
Drug repurposing has been shown to bring safe medications to new patient populations, as recently evidenced by the COVID-19 pandemic. We investigated whether we could use phenotypic screening to repurpose...
10.
Lapthorn A, Ilg M, Sullivan J, Dziewulski P, Cellek S
Eur J Pharmacol
. 2022 Nov;
937:175374.
PMID: 36343693
Although hypertrophic scarring affects ∼91% of burn patients annually, there is no drug to prevent this common complication. Hypertrophic scars are a result of dysregulated wound healing, characterised by persistent...