Stephen A Bustin
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Explore the profile of Stephen A Bustin including associated specialties, affiliations and a list of published articles.
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76
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Recent Articles
1.
Ilg M, Lapthorn A, Harding S, Minhas T, Koduri G, Bustin S, et al.
Front Pharmacol
. 2025 Feb;
16:1526495.
PMID: 40017592
Background: In cancer metastasis, tumor cells condition distant tissues to create a supportive environment, or metastatic niche, by driving the activation of cancer-associated fibroblasts (CAFs). These CAFs remodel the extracellular...
2.
Inhibition of phosphodiesterases 1 and 4 prevents myofibroblast transformation in Peyronie's disease
Harding S, Ilg M, Bustin S, Ralph D, Cellek S
BJU Int
. 2024 Dec;
PMID: 39716367
Objectives: To investigate which phosphodiesterase (PDE) isoforms are expressed in fibroblasts isolated from the tunica albuginea (TA) of patients with Peyronie's disease (PD), and to measure the potency of PDE...
3.
Bustin S
Int J Mol Sci
. 2024 Sep;
25(17).
PMID: 39273275
The COVID-19 pandemic highlighted the crucial role of diagnostic testing in managing infectious diseases, particularly through the use of reverse transcription-quantitative polymerase chain reaction (RT-qPCR) tests. RT-qPCR has been pivotal...
4.
Ilg M, Bustin S, Ralph D, Cellek S
Sci Rep
. 2024 May;
14(1):12389.
PMID: 38811625
Extracellular vesicles have emerged as important mediators of cell-to-cell communication in the pathophysiology of fibrotic diseases. One such disease is Peyronie's disease (PD), a fibrotic disorder of the penis caused...
5.
Bustin S, Kirvell S, Nolan T, Shipley G
Int J Mol Sci
. 2024 Mar;
25(5).
PMID: 38474020
Versatility, sensitivity, and accuracy have made the real-time polymerase chain reaction (qPCR) a crucial tool for research, as well as diagnostic applications. However, for point-of-care (PoC) use, traditional qPCR faces...
6.
Ilg M, Harding S, Lapthorn A, Kirvell S, Ralph D, Bustin S, et al.
J Sex Med
. 2024 Feb;
21(4):278-287.
PMID: 38383071
Background: Transformation of resident fibroblasts to profibrotic myofibroblasts in the tunica albuginea is a critical step in the pathophysiology of Peyronie's disease (PD). We have previously shown that myofibroblasts do...
7.
Bustin S
Mol Aspects Med
. 2024 Jan;
96:101249.
PMID: 38290180
The quantitative polymerase chain reaction (qPCR) is fundamental to molecular biology. It is not just a laboratory technique, qPCR is a bridge between research and clinical practice. Its theoretical foundations...
8.
Bustin S, Jellinger K
Int J Mol Sci
. 2023 Sep;
24(18).
PMID: 37762471
The escalating impacts of the climate crisis, zoonotic spill-over, and antibiotic resistance have positioned molecular medicine at the forefront of pioneering translational research [...].
9.
Bustin S
Int J Mol Sci
. 2023 Mar;
24(5).
PMID: 36902493
Molecular pathology, diagnostics and therapeutics are three closely related topics of critical importance in medical research and clinical practice [...].
10.
Bustin S, Shipley G, Kirvell S, Mueller R, Nolan T
Int J Mol Sci
. 2022 Feb;
23(3).
PMID: 35163227
Reverse transcription of RNA coupled to amplification of the resulting cDNA by the polymerase chain reaction (RT-PCR) is one of the principal molecular technologies in use today, with applications across...