Sebastien Coyne
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Explore the profile of Sebastien Coyne including associated specialties, affiliations and a list of published articles.
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11
Citations
669
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Recent Articles
1.
Couturier C, Ronzon Q, Lattanzi G, Lingard I, Coyne S, Cazals V, et al.
Eur J Med Chem
. 2023 Dec;
265:116097.
PMID: 38157595
Tridecaptins comprise a class of linear cationic lipopeptides with an N-terminal fatty acyl moiety. These 13-mer antimicrobial peptides consist of a combination of d- and l-amino acids, conferring increased proteolytic...
2.
Schuler S, Jurjens G, Marker A, Hemmann U, Rey A, Yvon S, et al.
Microbiol Spectr
. 2023 May;
11(3):e0224722.
PMID: 37140391
After the first total synthesis combined with structure revision, we performed thorough and profiling of the underexplored tetrapeptide GE81112A. From the determination of the biological activity spectrum and physicochemical and...
3.
Litomska A, Ishida K, Dunbar K, Boettger M, Coyne S, Hertweck C
Angew Chem Int Ed Engl
. 2018 Jun;
57(36):11574-11578.
PMID: 29947149
6-Thioguanine (6TG) is a DNA-targeting therapeutic used in the treatment of various cancers. While 6TG was rationally designed as a proof of concept for antimetabolite therapy, it is also a...
4.
Coyne S, Litomska A, Chizzali C, Khalil M, Richter K, Beerhues L, et al.
Chembiochem
. 2014 Jan;
15(3):373-6.
PMID: 24449489
Fire blight is a devastating disease of Rosaceae plants, such as apple and pear trees. It is characterized by necrosis of plant tissue, caused by the phytopathogenic bacterium Erwinia amylovora....
5.
Pidot S, Coyne S, Kloss F, Hertweck C
Int J Med Microbiol
. 2013 Oct;
304(1):14-22.
PMID: 24120363
The current crop of antibiotics in clinical use are either natural products or their derivatives. However, the rise of a multitude of different antibiotic resistant human pathogens has meant that...
6.
Coyne S, Chizzali C, Khalil M, Litomska A, Richter K, Beerhues L, et al.
Angew Chem Int Ed Engl
. 2013 Sep;
52(40):10564-8.
PMID: 24038828
Sulfur for fire: The molecular basis for the biosynthesis of the antimetabolite 6-thioguanine (6TG) was unveiled in Erwinia amylovora, the causative agent of fire blight. Bioinformatics, heterologous pathway reconstitution in...
7.
Lupo A, Coyne S, Berendonk T
Front Microbiol
. 2012 Feb;
3:18.
PMID: 22303296
The environment, and especially freshwater, constitutes a reactor where the evolution and the rise of new resistances occur. In water bodies such as waste water effluents, lakes, and rivers or...
8.
Coyne S, Courvalin P, Perichon B
Antimicrob Agents Chemother
. 2010 Dec;
55(3):947-53.
PMID: 21173183
Among Acinetobacter spp., A. baumannii is the most frequently implicated in nosocomial infections, in particular in intensive care units. It was initially thought that multidrug resistance (MDR) in this species...
9.
Coyne S, Rosenfeld N, Lambert T, Courvalin P, Perichon B
Antimicrob Agents Chemother
. 2010 Aug;
54(10):4389-93.
PMID: 20696879
Acinetobacter baumannii is a major nosocomial pathogen which frequently develops multidrug resistance by acquisition of antibiotic resistance genes and overexpression of intrinsic efflux systems, such as the RND efflux pumps...
10.
Coyne S, Courvalin P, Galimand M
Microbiology (Reading)
. 2010 Jan;
156(Pt 5):1448-1458.
PMID: 20110294
Pseudomonas aeruginosa is a major human opportunistic pathogen, especially for patients in intensive care units or with cystic fibrosis. Multidrug resistance is a common feature of this species. In a...