Sebastian Pott
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Explore the profile of Sebastian Pott including associated specialties, affiliations and a list of published articles.
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31
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1418
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Recent Articles
1.
Zhao Y, Zhou R, Xie B, Liu C, Kalski M, Cham C, et al.
Nat Commun
. 2025 Jan;
16(1):904.
PMID: 39837850
Total proctocolectomy with ileal pouch anal anastomosis is the standard of care for patients with severe ulcerative colitis. We generated a cell-type-resolved transcriptional and epigenetic atlas of ileal pouches using...
2.
Zhao Y, Zhou R, Mu Z, Carbonetto P, Zhong X, Xie B, et al.
medRxiv
. 2024 Dec;
PMID: 39711713
Crohn's disease (CD) is a complex inflammatory bowel disease resulting from an interplay of genetic, microbial, and environmental factors. Cell-type-specific contributions to CD etiology and genetic risk are incompletely understood....
3.
Fiebig A, Schnizlein M, Pena-Rivera S, Trigodet F, Dubey A, Hennessy M, et al.
mBio
. 2023 Dec;
15(1):e0283023.
PMID: 38063424
The Gram-negative bacterium is a common member of the human gut microbiota that colonizes multiple host niches and can influence human physiology through a variety of mechanisms. Identification of genes...
4.
Zhao Y, Zhou R, Xie B, Liu C, Kalski M, Cham C, et al.
medRxiv
. 2023 Nov;
PMID: 38014192
Total proctocolectomy with ileal pouch anal anastomosis is the standard of care for patients with severe ulcerative colitis. We generated a cell-type-resolved transcriptional and epigenetic atlas of ileal pouches using...
5.
Carbonetto P, Luo K, Sarkar A, Hung A, Tayeb K, Pott S, et al.
Genome Biol
. 2023 Oct;
24(1):236.
PMID: 37858253
Parts-based representations, such as non-negative matrix factorization and topic modeling, have been used to identify structure from single-cell sequencing data sets, in particular structure that is not as well captured...
6.
Selewa A, Luo K, Wasney M, Smith L, Sun X, Tang C, et al.
Nat Commun
. 2023 Aug;
14(1):4999.
PMID: 37591828
Genome-wide association studies (GWAS) have linked hundreds of loci to cardiac diseases. However, in most loci the causal variants and their target genes remain unknown. We developed a combined experimental...
7.
Zilbauer M, James K, Kaur M, Pott S, Li Z, Burger A, et al.
Nat Rev Gastroenterol Hepatol
. 2023 May;
20(9):597-614.
PMID: 37258747
The number of studies investigating the human gastrointestinal tract using various single-cell profiling methods has increased substantially in the past few years. Although this increase provides a unique opportunity for...
8.
Fiebig A, Schnizlein M, Pena-Rivera S, Trigodet F, Dubey A, Hennessy M, et al.
bioRxiv
. 2023 May;
PMID: 37214927
comprises 1-5% of the gut microbiota in healthy humans but can expand to >50% of the population in ulcerative colitis (UC) patients experiencing inflammation. The mechanisms underlying such microbial blooms...
9.
Heuberger C, Janney A, Ilott N, Bertocchi A, Pott S, Gu Y, et al.
Mucosal Immunol
. 2023 May;
17(3):416-430.
PMID: 37209960
Although intestinal epithelial cells (IECs) can express major histocompatibility complex class II (MHC II), especially during intestinal inflammation, it remains unclear if antigen presentation by IECs favors pro- or anti-inflammatory...
10.
Perrault E, Shireman J, Ali E, Lin P, Preddy I, Park C, et al.
Sci Adv
. 2023 May;
9(20):eade7236.
PMID: 37196077
During therapy, adaptations driven by cellular plasticity are partly responsible for driving the inevitable recurrence of glioblastoma (GBM). To investigate plasticity-induced adaptation during standard-of-care chemotherapy temozolomide (TMZ), we performed in...