Sebastian N W Hoernstein
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Explore the profile of Sebastian N W Hoernstein including associated specialties, affiliations and a list of published articles.
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21
Citations
377
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Recent Articles
1.
Milferstaedt S, Joest M, Bohlender L, Hoernstein S, Ozdemir B, Decker E, et al.
Sci Rep
. 2025 Jan;
15(1):3095.
PMID: 39856123
Bacterial cell division and plant chloroplast division require selfassembling Filamentous temperature-sensitive Z (FtsZ) proteins. FtsZ proteins are GTPases sharing structural and biochemical similarities with eukaryotic tubulin. In the moss Physcomitrella,...
2.
Hoernstein S, Schlosser A, Fiedler K, van Gessel N, Igloi G, Lang D, et al.
Plant Cell Rep
. 2024 Oct;
43(10):250.
PMID: 39361041
Analysis of the N-terminome of Physcomitrella reveals N-terminal monomethylation of nuclear-encoded, mitochondria-localized proteins. Post- or co-translational N-terminal modifications of proteins influence their half-life as well as mediating protein sorting to...
3.
Rempfer C, Hoernstein S, van Gessel N, Graf A, Spiegelhalder R, Bertolini A, et al.
Comput Struct Biotechnol J
. 2024 Jul;
23:2580-2594.
PMID: 39021582
Hydroxylation of prolines to 4-trans-hydroxyproline (Hyp) is mediated by prolyl-4 hydroxylases (P4Hs). In plants, Hyps occur in Hydroxyproline-rich glycoproteins (HRGPs), and are frequently -glycosylated. While both modifications are important, for...
4.
Niederau P, Egle P, Willig S, Parsons J, Hoernstein S, Decker E, et al.
Plant Cell Rep
. 2024 Jan;
43(2):43.
PMID: 38246952
Characterization of Physcomitrella 3'UTRs across different promoters yields endogenous single and double terminators for usage in molecular pharming. The production of recombinant proteins for health applications accounts for a large...
5.
Koselski M, Hoernstein S, Wasko P, Reski R, Trebacz K
Plant Cell Physiol
. 2023 May;
64(8):880-892.
PMID: 37233615
Electrical and calcium signals in plants are some of the basic carriers of information that are transmitted over a long distance. Together with reactive oxygen species (ROS) waves, electrical and...
6.
Hoernstein S, Ozdemir B, van Gessel N, Miniera A, von Bieberstein B, Nilges L, et al.
Commun Biol
. 2023 Jan;
6(1):61.
PMID: 36650210
Reactive oxygen species (ROS) are constant by-products of aerobic life. In excess, ROS lead to cytotoxic protein aggregates, which are a hallmark of ageing in animals and linked to age-related...
7.
Bohlender L, Parsons J, Hoernstein S, Bangert N, Rodriguez-Jahnke F, Reski R, et al.
Front Bioeng Biotechnol
. 2022 Mar;
10:838365.
PMID: 35252146
As biopharmaceuticals, recombinant proteins have become indispensable tools in medicine. An increasing demand, not only in quantity but also in diversity, drives the constant development and improvement of production platforms....
8.
Ruiz-Molina N, Parsons J, Muller M, Hoernstein S, Bohlender L, Pumple S, et al.
Commun Biol
. 2022 Feb;
5(1):152.
PMID: 35194132
The complement system constitutes the innate defense against pathogens. Its dysregulation leads to diseases and is a critical determinant in many viral infections, e.g., COVID-19. Factor H (FH) is the...
9.
Top O, Milferstaedt S, van Gessel N, Hoernstein S, Ozdemir B, Decker E, et al.
Commun Biol
. 2021 Aug;
4(1):964.
PMID: 34385580
Production of biopharmaceuticals relies on the expression of mammalian cDNAs in host organisms. Here we show that the expression of a human cDNA in the moss Physcomitrium patens generates the...
10.
Bohlender L, Parsons J, Hoernstein S, Rempfer C, Ruiz-Molina N, Lorenz T, et al.
Front Plant Sci
. 2021 Jan;
11:610032.
PMID: 33391325
Recombinantly produced proteins are indispensable tools for medical applications. Since the majority of them are glycoproteins, their -glycosylation profiles are major determinants for their activity, structural properties and safety. For...