Sebastian Heer
Overview
Explore the profile of Sebastian Heer including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
229
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0
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Recent Articles
1.
Lu B, Lucca L, Lewis W, Wang J, Nogueira C, Heer S, et al.
Nat Immunol
. 2024 Nov;
26(1):82-91.
PMID: 39609626
Effective anti-tumor immunity is driven by cytotoxic CD8 T cells with specificity for tumor antigens. However, the factors that control successful tumor rejection are not well understood. Here we identify...
2.
Hafler D, Lu B, Lucca L, Lewis W, Wang J, Nogeuira C, et al.
Res Sq
. 2024 Mar;
PMID: 38464315
Effective anti-tumor immunity is largely driven by cytotoxic CD8 T cells that can specifically recognize tumor antigens. However, the factors which ultimately dictate successful tumor rejection remain poorly understood. Here...
3.
Tortola L, Piattini F, Hausmann A, Ampenberger F, Rosenwald E, Heer S, et al.
Mucosal Immunol
. 2022 May;
15(4):656-667.
PMID: 35589985
Nuclear factor-κB (NF-κB) is a transcription factor with a key role in a great variety of cellular processes from embryonic development to immunity, the outcome of which depends on the...
4.
Obermair F, Renoux F, Heer S, Lee C, Cereghetti N, Loi M, et al.
Sci Adv
. 2022 Apr;
8(17):eabl5394.
PMID: 35486722
Understanding peptide presentation by specific MHC alleles is fundamental for controlling physiological functions of T cells and harnessing them for therapeutic use. However, commonly used in silico predictions and mass...
5.
Muri J, Thut H, Heer S, Krueger C, Bornkamm G, Bachmann M, et al.
Eur J Immunol
. 2019 Feb;
49(5):709-723.
PMID: 30802940
Antioxidant systems maintain cellular redox homeostasis. The thioredoxin-1 (Trx1) and the glutathione (GSH)/glutaredoxin-1 (Grx1) systems are key players in preserving cytosolic redox balance. In fact, T lymphocytes critically rely on...
6.
Muri J, Heer S, Matsushita M, Pohlmeier L, Tortola L, Fuhrer T, et al.
Nat Commun
. 2018 May;
9(1):1851.
PMID: 29749372
The thioredoxin-1 (Trx1) system is an important contributor to cellular redox balance and is a sensor of energy and glucose metabolism. Here we show critical c-Myc-dependent activation of the Trx1...
7.
Freigang S, Ampenberger F, Spohn G, Heer S, Shamshiev A, Kisielow J, et al.
Eur J Immunol
. 2011 Apr;
41(7):2040-51.
PMID: 21484785
Oxidative stress and inflammation--two components of the natural host response to injury--constitute important etiologic factors in atherogenesis. The pro-inflammatory cytokine interleukin (IL)-1 significantly enhances atherosclerosis, however, the molecular mechanisms of...