Sebastian D Mackowiak
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Explore the profile of Sebastian D Mackowiak including associated specialties, affiliations and a list of published articles.
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22
Citations
7460
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Recent Articles
1.
Naderi J, Magalhaes A, Kibar G, Stik G, Zhang Y, Mackowiak S, et al.
Nat Cell Biol
. 2024 Jul;
26(8):1309-1321.
PMID: 38969762
Transcription factors (TFs) control specificity and activity of gene transcription, but whether a relationship between these two features exists is unclear. Here we provide evidence for an evolutionary trade-off between...
2.
Messingschlager M, Bartel-Steinbach M, Mackowiak S, Denkena J, Bieg M, Klos M, et al.
Environ Res
. 2023 Jun;
233:116413.
PMID: 37343754
While the link between exposure to high levels of ambient particulate matter (PM) and increased incidences of respiratory and cardiovascular diseases is widely recognized, recent epidemiological studies have shown that...
3.
Landshammer A, Bolondi A, Kretzmer H, Much C, Buschow R, Rose A, et al.
Elife
. 2023 Jan;
12.
PMID: 36719724
Long non-coding RNAs (lncRNAs) have emerged as fundamental regulators in various biological processes, including embryonic development and cellular differentiation. Despite much progress over the past decade, the genome-wide annotation of...
4.
Thurmann L, Klos M, Mackowiak S, Bieg M, Bauer T, Ishaque N, et al.
Allergy
. 2023 Jan;
78(6):1489-1506.
PMID: 36704932
Background: Childhood asthma is a result of a complex interaction of genetic and environmental components causing epigenetic and immune dysregulation, airway inflammation and impaired lung function. Although different microarray based...
5.
Tiesmeyer S, Sahay S, Muller-Botticher N, Eils R, Mackowiak S, Ishaque N
Front Genet
. 2022 Mar;
13:785877.
PMID: 35295943
The combination of a cell's transcriptional profile and location defines its function in a spatial context. Spatially resolved transcriptomics (SRT) has emerged as the assay of choice for characterizing cells...
6.
Ganez-Zapater A, Mackowiak S, Guo Y, Tarbier M, Jordan-Pla A, Friedlander M, et al.
Mol Genet Genomics
. 2022 Feb;
297(2):463-484.
PMID: 35187582
BRG1 and BRM are ATPase core subunits of the human SWI/SNF chromatin remodelling complexes mainly associated with transcriptional initiation. They also have a role in alternative splicing, which has been...
7.
Tarbier M, Mackowiak S, Frade J, Catuara-Solarz S, Biryukova I, Gelali E, et al.
Nat Commun
. 2020 Oct;
11(1):5445.
PMID: 33116115
Single-cell RNA sequencing studies on gene co-expression patterns could yield important regulatory and functional insights, but have so far been limited by the confounding effects of differentiation and cell cycle....
8.
Jaeger M, Schwalb B, Mackowiak S, Velychko T, Hanzl A, Imrichova H, et al.
Nat Genet
. 2020 Jun;
52(7):719-727.
PMID: 32483291
The Mediator complex directs signals from DNA-binding transcription factors to RNA polymerase II (Pol II). Despite this pivotal position, mechanistic understanding of Mediator in human cells remains incomplete. Here we...
9.
Basu S, Mackowiak S, Niskanen H, Knezevic D, Asimi V, Grosswendt S, et al.
Cell
. 2020 May;
181(5):1062-1079.e30.
PMID: 32386547
Expansions of amino acid repeats occur in >20 inherited human disorders, and many occur in intrinsically disordered regions (IDRs) of transcription factors (TFs). Such diseases are associated with protein aggregation,...
10.
Nehammer C, Podolska A, Mackowiak S, Kagias K, Pocock R
Sci Rep
. 2019 May;
9(1):7619.
PMID: 31110188
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