Nikolaus Rajewsky
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Explore the profile of Nikolaus Rajewsky including associated specialties, affiliations and a list of published articles.
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151
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34059
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Recent Articles
1.
Schneeberger S, Kim S, Geesdorf M, Friebel E, Eede P, Jendrach M, et al.
Nat Aging
. 2025 Mar;
PMID: 40082619
Neuroinflammation including interleukin (IL)-12/IL-23-signaling is central to Alzheimer's disease (AD) pathology. Inhibition of p40, a subunit of IL-12/IL-23, attenuates pathology in AD-like mice; however, its signaling mechanism and expression pattern...
2.
Schott M, Leon-Perinan D, Splendiani E, Ferretti E, Macino G, Karaiskos N, et al.
STAR Protoc
. 2024 Dec;
6(1):103521.
PMID: 39708325
Spatial transcriptomics (ST) is fundamental for understanding molecular mechanisms in health and disease. Here, we present a protocol for efficient and high-resolution ST in 2D/3D with Open-ST. We describe all...
3.
Pentimalli T, Karaiskos N, Rajewsky N
Annu Rev Pathol
. 2024 Oct;
20(1):405-432.
PMID: 39476415
Pathology has always been fueled by technological advances. Histology powered the study of tissue architecture at single-cell resolution and remains a cornerstone of clinical pathology today. In the last decade,...
4.
Al-Diab O, Sunkel C, Blanc E, Catar R, Ashraf M, Zhao H, et al.
Biol Sex Differ
. 2024 Sep;
15(1):72.
PMID: 39278930
Background: Sex differences exist in the prevalence and progression of major glomerular diseases. Podocytes are the essential cell-type in the kidney which maintain the physiological blood-urine barrier, and pathological changes...
5.
Lisowski P, Lickfett S, Rybak-Wolf A, Menacho C, Le S, Pentimalli T, et al.
Nat Commun
. 2024 Aug;
15(1):7027.
PMID: 39174523
Expansion of the glutamine tract (poly-Q) in the protein huntingtin (HTT) causes the neurodegenerative disorder Huntington's disease (HD). Emerging evidence suggests that mutant HTT (mHTT) disrupts brain development. To gain...
6.
Schott M, Leon-Perinan D, Splendiani E, Strenger L, Licha J, Pentimalli T, et al.
Cell
. 2024 Jun;
187(15):3953-3972.e26.
PMID: 38917789
Spatial transcriptomics (ST) methods unlock molecular mechanisms underlying tissue development, homeostasis, or disease. However, there is a need for easy-to-use, high-resolution, cost-efficient, and 3D-scalable methods. Here, we report Open-ST, a...
7.
Cerda-Jara C, Kim S, Thomas G, Farsi Z, Zolotarov G, Dube G, et al.
EMBO Rep
. 2024 Jun;
25(7):3008-3039.
PMID: 38831125
The circular RNA (circRNA) Cdr1as is conserved across mammals and highly expressed in neurons, where it directly interacts with microRNA miR-7. However, the biological function of this interaction is unknown....
8.
Liu H, Arsie R, Schwabe D, Schilling M, Minia I, Alles J, et al.
Mol Syst Biol
. 2024 May;
19(10):1-23.
PMID: 38778223
RNA abundance is tightly regulated in eukaryotic cells by modulating the kinetic rates of RNA production, processing, and degradation. To date, little is known about time‐dependent kinetic rates during dynamic...
9.
Wandres M, Aigner D, Kastelic N, Boltengagen A, Rybak-Wolf A, Rajewsky N
J Vis Exp
. 2024 Apr;
(205).
PMID: 38619271
Over the past decade, single-cell transcriptomics has significantly evolved and become a standard laboratory method for simultaneous analysis of gene expression profiles of individual cells, allowing the capture of cellular...
10.
Scoyni F, Sitnikova V, Giudice L, Korhonen P, Trevisan D, Hernandez de Sande A, et al.
Cell Rep
. 2024 Mar;
43(3):113862.
PMID: 38446664
Brain functionality relies on finely tuned regulation of gene expression by networks of non-coding RNAs (ncRNAs) such as the one composed by the circular RNA ciRS-7 (also known as CDR1as),...