Sebastian Altenhofer
Overview
Explore the profile of Sebastian Altenhofer including associated specialties, affiliations and a list of published articles.
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10
Citations
781
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Recent Articles
1.
Thao-Vi Dao V, Elbatreek M, Altenhofer S, Casas A, Pachado M, Neullens C, et al.
Free Radic Biol Med
. 2019 Dec;
148:60-69.
PMID: 31883469
Dysfunctional reactive oxygen species (ROS) signaling is considered an important disease mechanism. Therapeutically, non-selective scavenging of ROS by antioxidants, however, has failed in multiple clinical trials to provide patient benefit....
2.
Altenhofer S, Radermacher K, Kleikers P, Wingler K, Schmidt H
Antioxid Redox Signal
. 2014 Jan;
23(5):406-27.
PMID: 24383718
Significance: Oxidative stress, an excess of reactive oxygen species (ROS) production versus consumption, may be involved in the pathogenesis of different diseases. The only known enzymes solely dedicated to ROS...
3.
Radermacher K, Wingler K, Langhauser F, Altenhofer S, Kleikers P, Hermans J, et al.
Antioxid Redox Signal
. 2012 Sep;
18(12):1418-27.
PMID: 22937798
Significance: Stroke, a leading cause of death and disability, poses a substantial burden for patients, relatives, and our healthcare systems. Only one drug is approved for treating stroke, and more...
4.
Altenhofer S, Kleikers P, Radermacher K, Scheurer P, Hermans J, Schiffers P, et al.
Cell Mol Life Sci
. 2012 Jun;
69(14):2327-43.
PMID: 22648375
Reactive oxygen species (ROS) are cellular signals but also disease triggers; their relative excess (oxidative stress) or shortage (reductive stress) compared to reducing equivalents are potentially deleterious. This may explain...
5.
Radermacher K, Wingler K, Kleikers P, Altenhofer S, Jr Hermans J, Kleinschnitz C, et al.
Exp Transl Stroke Med
. 2012 May;
4(1):11.
PMID: 22625431
As recently reviewed, 1026 neuroprotective drug candidates in stroke research have all failed on their road towards validation and clinical translation, reasons being quality issues in preclinical research and publication...
6.
Altenhofer S, Witte I, Teiber J, Wilgenbus P, Pautz A, Li H, et al.
J Biol Chem
. 2010 Jun;
285(32):24398-403.
PMID: 20530481
The human enzyme paraoxonase-2 (PON2) has two functions, an enzymatic lactonase activity and the reduction of intracellular oxidative stress. As a lactonase, it dominantly hydrolyzes bacterial signaling molecule 3OC12 and...
7.
Horke S, Witte I, Altenhofer S, Wilgenbus P, Goldeck M, Forstermann U, et al.
Biochem J
. 2009 Nov;
426(1):73-83.
PMID: 19925453
Two virulence factors produced by Pseudomonas aeruginosa are pyocyanin and N-(3-oxododecanoyl)-L-homoserine lactone (3OC12). Pyocyanin damages host cells by generating ROS (reactive oxygen species). 3OC12 is a quorum-sensing signalling molecule which...
8.
Pautz A, Linker K, Altenhofer S, Heil S, Schmidt N, Art J, et al.
J Biol Chem
. 2008 Dec;
284(5):2755-2766.
PMID: 19074427
The ARE/poly-(U) binding factor 1 (AUF1), a protein family consisting of four isoforms, is believed to mediate mRNA degradation by binding to AU-rich elements (ARE). However, evidence exists that individual...
9.
Horke S, Witte I, Wilgenbus P, Altenhofer S, Kruger M, Li H, et al.
Biochem J
. 2008 Aug;
416(3):395-405.
PMID: 18691157
PON2 (paraoxonase-2) is a ubiquitously expressed antioxidative protein which is largely found in the ER (endoplasmic reticulum). Addressing the cytoprotective functions of PON2, we observed that PON2 overexpression provided significant...
10.
Pautz A, Linker K, Hubrich T, Korhonen R, Altenhofer S, Kleinert H
J Biol Chem
. 2006 Sep;
281(43):32294-302.
PMID: 16950790
Human inducible nitric oxide synthase (iNOS) expression is regulated by transcriptional and post-transcriptional mechanisms. We have recently shown that the multifunctional RNA-binding proteins KH-type splicing regulatory protein and tristetraprolin are...