Harald H H W Schmidt
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Explore the profile of Harald H H W Schmidt including associated specialties, affiliations and a list of published articles.
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115
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6601
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Recent Articles
1.
Sedding D, Schmidt T, Bahre H, Bavendiek U, Casas A, Chen S, et al.
JACC Adv
. 2025 Feb;
4(3):101590.
PMID: 39985883
Background: Peripheral artery disease (PAD) is a major public health concern due to its high prevalence, severe impact on individuals' health and quality of life, and substantial economic burden. Pharmacological...
2.
Scholte M, Grimm S, Pauly B, Verbeeck F, Pasmooij A, Bouma B, et al.
Drug Discov Today
. 2025 Jan;
30(1):104286.
PMID: 39756647
Repurposing off-patent drugs can be a potential source of low-cost treatments for patients with unmet medical needs. Here, we review the proposed new European Union (EU) pharmaceutical legislation in which...
3.
Alexander S, Fabbro D, Kelly E, Mathie A, Peters J, Veale E, et al.
Br J Pharmacol
. 2023 Dec;
180 Suppl 2:S241-S288.
PMID: 38123155
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of...
4.
Pacheco Pachado M, Casas A, Elbatreek M, Nogales C, Guney E, Espay A, et al.
J Alzheimers Dis
. 2023 Sep;
96(1):47-56.
PMID: 37742653
Alzheimer's disease (AD) and other forms of dementia are together a leading cause of disability and death in the aging global population, imposing a high personal, societal, and economic burden....
5.
Matschinske J, Spath J, Bakhtiari M, Probul N, Kazemi Majdabadi M, Nasirigerdeh R, et al.
J Med Internet Res
. 2023 Jul;
25:e42621.
PMID: 37436815
Background: Machine learning and artificial intelligence have shown promising results in many areas and are driven by the increasing amount of available data. However, these data are often distributed across...
6.
Nelissen E, van Hagen B, Argyrousi E, van Goethem N, Heckman P, Paes D, et al.
Neurosci Lett
. 2022 Aug;
788:136840.
PMID: 35985509
Soluble guanylate cyclase (sGC) - cyclic guanosine monophosphate (cGMP) signalling is important for healthy memory function and a healthy vascular system. Targeting sGC-cGMP signalling can therefore be a potential strategy...
7.
Casas A, Hassan A, Manz Q, Wiwie C, Kleikers P, Egea J, et al.
Sci Rep
. 2022 Jul;
12(1):12324.
PMID: 35853974
Differential gene expression normalised to a single housekeeping (HK) is used to identify disease mechanisms and therapeutic targets. HK gene selection is often arbitrary, potentially introducing systematic error and discordant...
8.
Ho F, Watson A, Elbatreek M, Kleikers P, Khan W, Sourris K, et al.
Sci Rep
. 2022 Jul;
12(1):11570.
PMID: 35798762
Atherosclerosis and its complications are major causes of cardiovascular morbidity and death. Apart from risk factors such as hypercholesterolemia and inflammation, the causal molecular mechanisms are unknown. One proposed causal...
9.
Hartung M, Anastasi E, Mamdouh Z, Nogales C, Schmidt H, Baumbach J, et al.
Nucleic Acids Res
. 2022 May;
50(W1):W138-W144.
PMID: 35580047
Cancer is a heterogeneous disease characterized by unregulated cell growth and promoted by mutations in cancer driver genes some of which encode suitable drug targets. Since the distinct set of...
10.
Jha J, Dai A, Garzarella J, Charlton A, Urner S, Ostergaard J, et al.
Diabetes
. 2022 Mar;
71(6):1282-1298.
PMID: 35275988
Excessive production of renal reactive oxygen species (ROS) plays a major role in diabetic kidney disease (DKD). Here, we provide key findings demonstrating the predominant pathological role of the pro-oxidant...