Sean Mackay
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Explore the profile of Sean Mackay including associated specialties, affiliations and a list of published articles.
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57
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2247
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Recent Articles
1.
Root J, Desai P, Ly C, Wang B, Jelloul F, Zhou J, et al.
Cancer Res Commun
. 2024 Feb;
4(3):671-681.
PMID: 38391202
Significance: We found T-cell polyfunctionality differs between local and systemic microenvironments. Enhanced variability in proteomic profiles of bone marrow CD4 T cells post-IO suggests their pivotal role in AML treatment...
2.
Li D, Wang R, Liang T, Ren H, Park C, Tai C, et al.
Nat Commun
. 2023 Sep;
14(1):5920.
PMID: 37739951
Rational design of chimeric antigen receptor T (CAR-T) cells based on the recognition of antigenic epitopes capable of evoking the most potent CAR activation is an important objective in optimizing...
3.
Steen C, Lee J, Wong E, Mackay S
Case Rep Surg
. 2023 Jul;
2023:5361609.
PMID: 37427295
Bochdalek hernias (BHs) are rare, and the presentation, diagnosis, and management of them can be complex. We present a 70-year-old man presenting with left flank pain who underwent a successful...
4.
Disis M, Dang Y, Coveler A, Childs J, Higgins D, Liu Y, et al.
Clin Cancer Res
. 2023 Apr;
29(17):3362-3371.
PMID: 37093223
Purpose: High levels of type I T cells are needed for tumor eradication. We evaluated whether the HER2-specific vaccine-primed T cells are readily expanded ex vivo to achieve levels needed...
5.
Naulaerts S, Datsi A, Borras D, Antoranz Martinez A, Messiaen J, Vanmeerbeek I, et al.
Sci Transl Med
. 2023 Apr;
15(691):eadd1016.
PMID: 37043555
Clinically relevant immunological biomarkers that discriminate between diverse hypofunctional states of tumor-associated CD8 T cells remain disputed. Using multiomics analysis of CD8 T cell features across multiple patient cohorts and...
6.
Li N, Quan A, Li D, Pan J, Ren H, Hoeltzel G, et al.
Nat Commun
. 2023 Apr;
14(1):1986.
PMID: 37031249
Heterogeneous antigen expression is a key barrier influencing the activity of chimeric antigen receptor (CAR) T cells in solid tumors. Here, we develop CAR T cells targeting glypican-1 (GPC1), an...
7.
Ni W, Han E, Cyr M, Mackay S, Zhou J
Proteomics
. 2023 Feb;
23(13-14):e2200242.
PMID: 36786585
Genetically and phenotypically identical immune cell populations can be highly heterogenous in terms of their immune functions and protein secretion profiles. The microfluidic chip-based single-cell highly multiplexed secretome proteomics enables...
8.
Nakate M, Mackay S, Ndirangu-Mugo E, Fleming V
BMC Pregnancy Childbirth
. 2022 Dec;
22(1):938.
PMID: 36522709
Background: COVID-19 presented an unprecedented global public health challenge because of its rapid and relentless spread, and many countries instituted lockdowns to prevent the spread of infection. Although this strategy...
9.
Kaur K, Chen P, Ko M, Mei A, Chovatiya N, Huerta-Yepez S, et al.
Cells
. 2022 Nov;
11(21).
PMID: 36359827
Amyotrophic lateral sclerosis (ALS) is an auto-immune neurodegenerative disorder affecting the motor-neuron system. The causes of ALS are heterogeneous, and are only partially understood. We studied different aspects of immune...
10.
Su Y, Yuan D, Chen D, Ng R, Wang K, Choi J, et al.
Cell
. 2022 Feb;
185(5):881-895.e20.
PMID: 35216672
Post-acute sequelae of COVID-19 (PASC) represent an emerging global crisis. However, quantifiable risk factors for PASC and their biological associations are poorly resolved. We executed a deep multi-omic, longitudinal investigation...