Sean G Smith
Overview
Explore the profile of Sean G Smith including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
331
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0
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Recent Articles
1.
Draugelis S, Brown E, Donahue D, Hickman J, Smith S, Sutherland P, et al.
PLOS Glob Public Health
. 2025 Jan;
5(1):e0003124.
PMID: 39879195
Humanitarian medical response to natural and human-made disasters can be complicated by high clinician, staff, and patient turnover. While electronic medical records are being scaled up globally, their use remains...
2.
Inniss M, Smith S, Li D, Primack B, Sun D, Olinger G, et al.
Commun Biol
. 2025 Jan;
8(1):28.
PMID: 39789216
Adoptive cell therapies (ACT) have shown reduced efficacy against solid tumor malignancies compared to hematologic malignancies, partly due to the immunosuppressive nature of the tumor microenvironment (TME). ACT efficacy may...
3.
Barberio A, Smith S, Pires I, Iyer S, Reinhardt F, Melo M, et al.
Bioeng Transl Med
. 2023 Mar;
8(2):e10453.
PMID: 36925719
Ovarian cancer is especially deadly, challenging to treat, and has proven refractory to known immunotherapies. Cytokine therapy is an attractive strategy to drive a proinflammatory immune response in immunologically cold...
4.
Li Z, Huang S, He Y, van Wijnbergen J, Zhang Y, Cottrell R, et al.
bioRxiv
. 2023 Jan;
PMID: 36711668
One Sentence Summary: We develop a real-time high contrast optical technique for imaging the lymphatic system, and apply it to anatomical pathology gross examination in a clinical setting, as well...
5.
Iyer S, Zhang S, Yucel S, Horn H, Smith S, Reinhardt F, et al.
Cancer Discov
. 2020 Nov;
11(2):384-407.
PMID: 33158843
Despite advances in immuno-oncology, the relationship between tumor genotypes and response to immunotherapy remains poorly understood, particularly in high-grade serous tubo-ovarian carcinomas (HGSC). We developed a series of mouse models...
6.
Barberio A, Smith S, Correa S, Nguyen C, Nhan B, Melo M, et al.
ACS Nano
. 2020 Jul;
14(9):11238-11253.
PMID: 32692155
Although cytokine therapy is an attractive strategy to build a more robust immune response in tumors, cytokines have faced clinical failures due to toxicity. In particular, interleukin-12 has shown great...
7.
Correa S, Boehnke N, Barberio A, Deiss-Yehiely E, Shi A, Oberlton B, et al.
ACS Nano
. 2020 Jan;
14(2):2224-2237.
PMID: 31971772
Nanoparticle surface chemistry is a fundamental engineering parameter that governs tumor-targeting activity. Electrostatic assembly generates controlled polyelectrolyte complexes through the process of adsorption and charge overcompensation utilizing synthetic polyions and...
8.
Ravindranathan S, Nguyen K, Kurtz S, Frazier H, Smith S, Koppolu B, et al.
Breast Cancer Res
. 2018 Oct;
20(1):126.
PMID: 30348199
Background: Although metastasis is ultimately responsible for about 90% of breast cancer mortality, the vast majority of breast-cancer-related deaths are due to progressive recurrences from non-metastatic disease. Current adjuvant therapies...
9.
Smith S, Griffith B, Zaharoff D
Math Med Biol
. 2018 Apr;
36(2):139-156.
PMID: 29659860
Ailments of the bladder are often treated via intravesical delivery-direct application of therapeutic into the bladder through a catheter. This technique is employed hundreds of thousands of times every year,...
10.
Jayanthi S, Koppolu B, Nguyen K, Smith S, Felber B, Kumar T, et al.
Sci Rep
. 2017 Jul;
7(1):5360.
PMID: 28706183
Glycosaminoglycans (GAGs), especially heparin and heparan sulfate (HS), modulate the functions of numerous cytokines. The aims of this multidisciplinary research were to characterize heparin binding to interleukin-12 (IL-12) and determine...