David A Zaharoff
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Explore the profile of David A Zaharoff including associated specialties, affiliations and a list of published articles.
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51
Citations
856
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Recent Articles
1.
Williamson R, DeWitt M, Elhanafi D, Zaharoff D, Sano M
IEEE Trans Biomed Eng
. 2025 Mar;
PP.
PMID: 40036516
Objective: Bipolar microsecond and submicrosecond pulsed electric fields have several advantages over longer duration monopolar pulses including significant reductions in muscle stimulation and perceived pain enabling their use in several...
2.
Weiss L, Schluck M, Classens R, de Jonge P, van der Waart A, Nguyen K, et al.
Acta Biomater
. 2024 Nov;
191:386-397.
PMID: 39528061
Immunotherapies are a powerful strategy to treat cancer by modulating the immune system to raise an anti-tumor immune response. A prime example of immunotherapies are cytokines - small immunomodulatory molecules...
3.
Safety and Pharmacokinetics of Intravesical Chitosan/Interleukin-12 Immunotherapy in Murine Bladders
Nguyen K, Wagner E, Vrabel M, Mantooth S, Meritet D, Zaharoff D
Bladder Cancer
. 2024 Jul;
7(4):427-437.
PMID: 38993985
Background: Intravesical administration of interleukin 12 (IL-12) co-formulated with the biopolymer, chitosan (CS/IL-12), has demonstrated remarkable antitumor activity against preclinical models of bladder cancer. However, given historical concerns regarding severe...
4.
Mantooth S, Abdou Y, Saez-Ibanez A, Upadhaya S, Zaharoff D
Front Immunol
. 2024 May;
15:1385484.
PMID: 38803496
Breast cancer poses one of the largest threats to women's health. Treatment continues to improve for all the subtypes of breast cancer, but some subtypes, such as triple negative breast...
5.
Rodriguez Troncoso J, Marium Mim U, Ivers J, Paidi S, Harper M, Nguyen K, et al.
Biomed Opt Express
. 2024 Feb;
14(12):6114-6126.
PMID: 38420330
We used diffuse reflectance spectroscopy to quantify tissue absorption and scattering-based parameters in similarly sized tumors derived from a panel of four isogenic murine breast cancer cell lines (4T1, 4T07,...
6.
Mantooth S, Hancock A, Thompson P, Varghese P J G, Meritet D, Vrabel M, et al.
ACS Biomater Sci Eng
. 2024 Jan;
10(2):905-920.
PMID: 38240491
Localized delivery of immunotherapeutics within a tumor has the potential to reduce systemic toxicities and improve treatment outcomes in cancer patients. Unfortunately, local retention of therapeutics following intratumoral injection is...
7.
Vrabel M, Fesmire C, Rich M, Kobrin R, Sano M, Zaharoff D
Cryobiology
. 2024 Jan;
114:104844.
PMID: 38171448
Cryoablation (CA) of solid tumors is highly effective at reducing tumor burden and eliminating small, early stage tumors. However, complete ablation is difficult to achieve and cancer recurrence is a...
8.
Zhang F, Gluck J, Brown A, Zaharoff D, King M
ACS Appl Mater Interfaces
. 2023 Jun;
15(23):27457-27470.
PMID: 37272781
Macrophages play a pivotal role in wound healing and tissue regeneration, as they are rapidly recruited to the site of injury or implanted foreign material. Depending on their interaction with...
9.
Vrabel M, Schulman J, Gillam F, Mantooth S, Nguyen K, Zaharoff D
Cancers (Basel)
. 2023 May;
15(8).
PMID: 37190138
Focal ablation technologies are routinely used in the clinical management of inoperable solid tumors but they often result in incomplete ablations leading to high recurrence rates. Adjuvant therapies, capable of...
10.
Huynh T, Reed C, Blackwell Z, Phelps P, Herrera L, Almodovar J, et al.
Sci Rep
. 2023 Feb;
13(1):1983.
PMID: 36737628
This study was designed to test the hypothesis that in addition to repairing the architectural and cellular cues via regenerative medicine, the delivery of immune cues (immunotherapy) may be needed...