Scott R Rajski
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Explore the profile of Scott R Rajski including associated specialties, affiliations and a list of published articles.
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54
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965
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Recent Articles
1.
Zhang F, Wang W, Braun D, Ananiev G, Liao W, Harper M, et al.
Mar Drugs
. 2025 Feb;
23(2).
PMID: 39997189
The discovery of new natural products remains a cornerstone of therapeutic innovation, and effective analytical tools for rapid dereplication can significantly accelerate this process. Using Isotopic Fine Structure (IFS) mass...
2.
Bell B, Anderson J, Rajski S, Bugni T
J Nat Prod
. 2025 Feb;
88(2):306-313.
PMID: 39929196
Metal chelating small molecules (metallophores) play significant roles in microbial interactions and bacterial survival; however, current methods to identify metallophores are limited by low sensitivity, a lack of metal selectivity,...
3.
Brittin N, Anderson J, Braun D, Rajski S, Currie C, Bugni T
J Nat Prod
. 2025 Feb;
88(2):361-372.
PMID: 39919314
The rediscovery of known drug classes represents a major challenge in natural products drug discovery. Compound rediscovery inhibits the ability of researchers to explore novel natural products and wastes significant...
4.
Brittin N, Aceti D, Braun D, Anderson J, Ericksen S, Rajski S, et al.
Molecules
. 2025 Jan;
30(1.
PMID: 39795134
Recently expanded reports of multidrug-resistant fungal infections underscore the need to develop new and more efficient methods for antifungal drug discovery. A ubiquitous problem in natural product drug discovery campaigns...
5.
Alas I, Braun D, Ericksen S, Salamzade R, Kalan L, Rajski S, et al.
Microb Genom
. 2024 Jan;
10(1).
PMID: 38175683
No abstract available.
6.
Yan J, Wu Q, Maity M, Braun D, Alas I, Wang X, et al.
Chemistry
. 2023 Jul;
29(56):e202301813.
PMID: 37452377
Cyclic peptides have been excellent source of drug leads. With the advances in discovery platforms, the pharmaceutical industry has a growing interest in cyclic peptides and has pushed several into...
7.
Wu Q, Bell B, Yan J, Chevrette M, Brittin N, Zhu Y, et al.
J Am Chem Soc
. 2022 Dec;
145(1):58-69.
PMID: 36535031
Although microbial genomes harbor an abundance of biosynthetic gene clusters, there remain substantial technological gaps that impair the direct correlation of newly discovered gene clusters and their corresponding secondary metabolite...
8.
Zhang F, Ramos Alvarenga R, Throckmorton K, Chanana S, Braun D, Fossen J, et al.
Org Lett
. 2022 Jun;
24(22):3998-4002.
PMID: 35649263
Pseudonochelin (), a siderophore from a marine-derived sp. bacterium, was discovered using genome mining and metabolomics technologies. A 5-aminosalicylic acid (5-ASA) unit, not previously found in siderophore natural products, was...
9.
Yan J, Wu Q, Helfrich E, Chevrette M, Braun D, Heyman H, et al.
Mar Drugs
. 2022 Jan;
20(1).
PMID: 35049898
Chemical investigations of a marine sponge-associated revealed six new imidazolium-containing compounds, bacillimidazoles A-F (-). Previous reports of related imidazolium-containing natural products are rare. Initially unveiled by timsTOF (trapped ion mobility...
10.
Zhao M, Zhang F, Zarnowski R, Barns K, Jones R, Fossen J, et al.
J Clin Invest
. 2020 Dec;
131(5).
PMID: 33373326
The emergence of drug-resistant fungi has prompted an urgent threat alert from the US Centers for Disease Control (CDC). Biofilm assembly by these pathogens further impairs effective therapy. We recently...