Scott Pletcher
Overview
Explore the profile of Scott Pletcher including associated specialties, affiliations and a list of published articles.
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8
Citations
1268
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0
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Recent Articles
1.
Rogina B, Anderson R, LeBrasseur N, Curan S, Yousefzadeh M, Ghosh B, et al.
J Gerontol A Biol Sci Med Sci
. 2025 Feb;
PMID: 39932386
The aging process is universal, and it is characterized by a progressive deterioration and decrease in physiological function leading to decline on the organismal level. Nevertheless, a number of genetic...
2.
Shell B, Luo Y, Pletcher S, Grotewiel M
Sci Rep
. 2021 Oct;
11(1):20044.
PMID: 34625601
The Drosophila model is used to investigate the effects of diet on physiology as well as the effects of genetic pathways, neural systems and environment on feeding behavior. We previously...
3.
Jensen L, Venkei Z, Watase G, Bisai B, Pletcher S, Lee C, et al.
J Cell Sci
. 2021 Jun;
134(14).
PMID: 34164657
Tissue-specific stem cells maintain tissue homeostasis by providing a continuous supply of differentiated cells throughout the life of organisms. Differentiated/differentiating cells can revert back to a stem cell identity via...
4.
Hahn O, Drews L, Nguyen A, Tatsuta T, Gkioni L, Hendrich O, et al.
Nat Metab
. 2019 Nov;
1(11):1059-1073.
PMID: 31742247
Dietary restriction (DR) during adulthood can greatly extend lifespan and improve metabolic health in diverse species. However, whether DR in mammals is still effective when applied for the first time...
5.
Miller R, Harrison D, Astle C, Fernandez E, Flurkey K, Han M, et al.
Aging Cell
. 2013 Dec;
13(3):468-77.
PMID: 24341993
Rapamycin, an inhibitor of mTOR kinase, increased median lifespan of genetically heterogeneous mice by 23% (males) to 26% (females) when tested at a dose threefold higher than that used in...
6.
Harrison D, Strong R, Allison D, Ames B, Astle C, Atamna H, et al.
Aging Cell
. 2013 Nov;
13(2):273-82.
PMID: 24245565
Four agents--acarbose (ACA), 17-α-estradiol (EST), nordihydroguaiaretic acid (NDGA), and methylene blue (MB)--were evaluated for lifespan effects in genetically heterogeneous mice tested at three sites. Acarbose increased male median lifespan by...
7.
Soibam B, Mann M, Liu L, Tran J, Lobaina M, Yuan Kang Y, et al.
Brain Behav
. 2012 May;
2(2):97-108.
PMID: 22574279
Drosophila adults, when placed into a novel open-field arena, initially exhibit an elevated level of activity followed by a reduced stable level of spontaneous activity and spend a majority of...
8.
Miller R, Harrison D, Astle C, Baur J, Boyd A, de Cabo R, et al.
J Gerontol A Biol Sci Med Sci
. 2010 Oct;
66(2):191-201.
PMID: 20974732
Rapamycin was administered in food to genetically heterogeneous mice from the age of 9 months and produced significant increases in life span, including maximum life span, at each of three...
9.
Gems D, Pletcher S, Partridge L
Aging Cell
. 2003 Jul;
1(1):1-9.
PMID: 12882347
A major challenge in current research into aging using model organisms is to establish whether different treatments resulting in slowed aging involve common or distinct mechanisms. Such treatments include gene...