Kevin Flurkey
Overview
Explore the profile of Kevin Flurkey including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
39
Citations
4367
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Mullis M, Wright K, Raj A, Gatti D, Reifsnyder P, Flurkey K, et al.
bioRxiv
. 2024 Nov;
PMID: 39605744
Lifespan is an integrative phenotype whose genetic architecture is likely to highlight multiple processes with high impact on health and aging. Here, we conduct a genetic meta-analysis of longevity in...
2.
Harrison D, Strong R, Reifsnyder P, Rosenthal N, Korstanje R, Fernandez E, et al.
Geroscience
. 2023 Dec;
46(1):795-816.
PMID: 38041783
In genetically heterogeneous (UM-HET3) mice produced by the CByB6F1 × C3D2F1 cross, the Nrf2 activator astaxanthin (Asta) extended the median male lifespan by 12% (p = 0.003, log-rank test), while...
3.
Reifsnyder P, Flurkey K, Doty R, Calcutt N, Koza R, Harrison D
Aging Cell
. 2022 Aug;
21(9):e13666.
PMID: 35986566
Rapamycin treatment has positive and negative effects on progression of type 2 diabetes (T2D) in a recombinant inbred polygenic mouse model, male NONcNZO10/LtJ (NcZ10). Here, we show that combination treatment...
4.
Harrison D, Strong R, Reifsnyder P, Kumar N, Fernandez E, Flurkey K, et al.
Aging Cell
. 2021 Mar;
20(5):e13328.
PMID: 33788371
In genetically heterogeneous mice produced by the CByB6F1 x C3D2F1 cross, the "non-feminizing" estrogen, 17-α-estradiol (17aE2), extended median male lifespan by 19% (p < 0.0001, log-rank test) and 11% (p ...
5.
Miller R, Harrison D, Astle C, Bogue M, Brind J, Fernandez E, et al.
Aging Cell
. 2019 Mar;
18(3):e12953.
PMID: 30916479
Diets low in methionine extend lifespan of rodents, though through unknown mechanisms. Glycine can mitigate methionine toxicity, and a small prior study has suggested that supplemental glycine could extend lifespan...
6.
Harrison D, Strong R, Alavez S, Astle C, DiGiovanni J, Fernandez E, et al.
Aging Cell
. 2019 Jan;
18(2):e12898.
PMID: 30688027
To follow-up on our previous report that acarbose (ACA), a drug that blocks postprandial glucose spikes, increases mouse lifespan, we studied ACA at three doses: 400, 1,000 (the original dose),...
7.
Reifsnyder P, Ryzhov S, Flurkey K, Anunciado-Koza R, Mills I, Harrison D, et al.
Ann N Y Acad Sci
. 2018 Jan;
1418(1):106-117.
PMID: 29377150
Rapamycin (RAPA), an inhibitor of mTORC signaling, has been shown to extend life span in mice and other organisms. Recently, animal and human studies have suggested that inhibition of mTORC...
8.
Lee B, Buric I, George-Pandeth A, Flurkey K, Harrison D, Yuan R, et al.
Sci Rep
. 2017 Mar;
7:44620.
PMID: 28304372
MicroRNAs (miRNAs) are small non-coding RNA species that have been shown to have roles in multiple processes that occur in higher eukaryotes. They act by binding to specific sequences in...
9.
Reifsnyder P, Flurkey K, Te A, Harrison D
Aging (Albany NY)
. 2016 Dec;
8(11):3120-3130.
PMID: 27922820
Numerous studies suggest that rapamycin treatment promotes insulin resistance, implying that rapamycin could have negative effects on patients with, or at risk for, type 2 diabetes (T2D). New evidence, however,...
10.
Lee B, Pilling L, Emond F, Flurkey K, Harrison D, Yuan R, et al.
Aging Cell
. 2016 Jul;
15(5):903-13.
PMID: 27363602
Dysregulation of splicing factor expression and altered alternative splicing are associated with aging in humans and other species, and also with replicative senescence in cultured cells. Here, we assess whether...