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Scott Pegan

Explore the profile of Scott Pegan including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 517
Followers 0
Related Specialties
Biochemistry
Biology
Science
Top 10 Co-Authors
Senyon Choe
Andrew D Mesecar
Paul A Slesinger
Michael E Johnson
Christine Arrabit
Witek Kwiatkowski
Roland Riek
Wentao Fu
Xi Qiu
Melissa Coughlin
Published In
Biochemistry
J Magn Reson
Bioorg Med Chem Lett
Nat Neurosci
Proc Natl Acad Sci U S A
Affiliations
Soon will be listed here.
Recent Articles
1.
Isolation and evaluation of kaempferol glycosides from the fern Neocheiropteris palmatopedata
Yang J, Kondratyuk T, Marler L, Qiu X, Choi Y, Cao H, et al.
Phytochemistry . 2010 Jan; 71(5-6):641-7. PMID: 20100622
Kaempferol glycosides, named palmatosides A (1), B (2) and C (3), together with three known kaempferol glycosides, multiflorins A (4) and B (5), and afzelin (6), were isolated from the...
2.
A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication
Ratia K, Pegan S, Takayama J, Sleeman K, Coughlin M, Baliji S, et al.
Proc Natl Acad Sci U S A . 2008 Oct; 105(42):16119-24. PMID: 18852458
We report the discovery and optimization of a potent inhibitor against the papain-like protease (PLpro) from the coronavirus that causes severe acute respiratory syndrome (SARS-CoV). This unique protease is not...
3.
Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase
Tipparaju S, Joyasawal S, Forrester S, Mulhearn D, Pegan S, Johnson M, et al.
Bioorg Med Chem Lett . 2008 May; 18(12):3565-9. PMID: 18499454
Enoyl-ACP reductase (ENR), the product of the FabI gene, from Bacillus anthracis (BaENR) is responsible for catalyzing the final step of bacterial fatty acid biosynthesis. A number of novel 2-pyridone...
4.
NMR studies of interactions between C-terminal tail of Kir2.1 channel and PDZ1,2 domains of PSD95
Pegan S, Tan J, Huang A, Slesinger P, Riek R, Choe S
Biochemistry . 2007 Apr; 46(18):5315-22. PMID: 17437338
Control of surface expression of inwardly rectifying potassium (Kir) channels is important for regulating membrane excitability. Kir2 channels have been shown to interact directly with PDZ-containing proteins in the postsynaptic...
5.
Andersen's syndrome mutation effects on the structure and assembly of the cytoplasmic domains of Kir2.1
Pegan S, Arrabit C, Slesinger P, Choe S
Biochemistry . 2006 Jul; 45(28):8599-606. PMID: 16834334
Kir2.1 channels play a key role in maintaining the correct resting potential in eukaryotic cells. Recently, specific amino acid mutations in the Kir2.1 inwardly rectifying potassium channel have been found...
6.
Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification
Pegan S, Arrabit C, Zhou W, Kwiatkowski W, Collins A, Slesinger P, et al.
Nat Neurosci . 2005 Feb; 8(3):279-87. PMID: 15723059
N- and C-terminal cytoplasmic domains of inwardly rectifying K (Kir) channels control the ion-permeation pathway through diverse interactions with small molecules and protein ligands in the cytoplasm. Two new crystal...
7.
High-throughput backbone resonance assignment of small 13C,15N-labeled proteins by a triple-resonance experiment with four sequential connectivity pathways using chemical shift-dependent, apparent 1J(1H,13C): HNCACBcodedHAHB
Pegan S, Kwiatkowski W, Choe S, Riek R
J Magn Reson . 2003 Dec; 165(2):315-9. PMID: 14643715
The proposed three-dimensional triple-resonance experiment HNCACBcodedHAHB correlates sequential 15N, 1H moieties via the chemical shifts of 13Calpha, 13Cbeta, 1Halpha, and 1Hbeta. The four sequential correlation pathways are achieved by the...