Scott Ness
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Explore the profile of Scott Ness including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
128
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Recent Articles
1.
Yu H, Jiang L, Li C, Ness S, Piccirillo S, Guo Y
Bioinformatics
. 2023 Aug;
39(9).
PMID: 37624931
Motivation: As an important player in transcriptome regulation, microRNAs may effectively diffuse somatic mutation impacts to broad cellular processes and ultimately manifest disease and dictate prognosis. Previous studies that tried...
2.
Yu H, Ness S, Li C, Bai Y, Mao P, Guo Y
Genome Res
. 2022 Sep;
32(10):1930-1940.
PMID: 36100435
Mutation density patterns reveal unique biological properties of specific genomic regions and shed light on the mechanisms of carcinogenesis. Although previous studies reported insightful mutation density patterns associated with certain...
3.
Jiang L, Yu H, Ness S, Mao P, Guo F, Tang J, et al.
Cancers (Basel)
. 2022 Jan;
14(2).
PMID: 35053577
Somatic mutations are one of the most important factors in tumorigenesis and are the focus of most cancer-sequencing efforts. The co-occurrence of multiple mutations in one tumor has gained increasing...
4.
Jiang L, Guo F, Tang J, Yu H, Ness S, Duan M, et al.
Nucleic Acids Res
. 2021 Oct;
50(1):e4.
PMID: 34606615
Efficient annotation of alterations in binding sequences of molecular regulators can help identify novel candidates for mechanisms study and offer original therapeutic hypotheses. In this work, we developed Somatic Binding...
5.
Wang J, Ness S, Brown R, Yu H, Oyebamiji O, Jiang L, et al.
Genomics
. 2021 Sep;
113(6):3864-3871.
PMID: 34562567
RNA editing exerts critical impacts on numerous biological processes. While millions of RNA editings have been identified in humans, much more are expected to be discovered. In this work, we...
6.
Guo Y, Yu H, Song H, He J, Oyebamiji O, Kang H, et al.
PLoS Comput Biol
. 2021 May;
17(5):e1008976.
PMID: 33945541
Analyses of gene set differential coexpression may shed light on molecular mechanisms underlying phenotypes and diseases. However, differential coexpression analyses of conceptually similar individual studies are often inconsistent and underpowered...
7.
Sheng Q, Yu H, Duan M, Ness S, He J, Kang H, et al.
Nat Protoc
. 2021 Mar;
16(4):2190-2212.
PMID: 33731963
UV radiation may lead to melanoma and nonmelanoma skin cancers by causing helix-distorting DNA damage such as cyclobutane pyrimidine dimers (CPDs). These DNA lesions, if located in important genes and...
8.
Jiang L, Guo F, Tang J, Leng S, Ness S, Ye F, et al.
Cancers (Basel)
. 2020 Dec;
12(12).
PMID: 33291726
Global autozygosity quantifies the genome-wide levels of homozygous and heterozygous variants. It is the signature of non-random reproduction, though it can also be driven by other factors, and has been...
9.
Jiang L, Duan M, Guo F, Tang J, Oybamiji O, Yu H, et al.
NAR Cancer
. 2020 Oct;
2(4):zcaa030.
PMID: 33094288
Binding motifs for transcription factors, RNA-binding proteins, microRNAs (miRNAs), etc. are vital for proper gene transcription and translation regulation. Sequence alteration mechanisms including single nucleotide mutations, insertion, deletion, RNA editing...
10.
Samuels D, Below J, Ness S, Yu H, Leng S, Guo Y
Trends Genet
. 2020 Aug;
36(11):857-867.
PMID: 32773169
One of the forerunners that pioneered the revolution of high-throughput genomic technologies is the genotyping microarray technology, which can genotype millions of single-nucleotide variants simultaneously. Owing to apparent benefits, such...