Scott M MacKenzie
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Explore the profile of Scott M MacKenzie including associated specialties, affiliations and a list of published articles.
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38
Citations
954
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Recent Articles
1.
MacKenzie S, Birch L, Lamprou S, Rezvanisanijouybari P, Fayad M, Zennaro M, et al.
Vitam Horm
. 2024 Feb;
124:137-163.
PMID: 38408798
Aldosterone is a cardiovascular hormone with a key role in blood pressure regulation, among other processes, mediated through its targeting of the mineralocorticoid receptor in the renal tubule and selected...
2.
Armignacco R, Reel P, Reel S, Jouinot A, Septier A, Gaspar C, et al.
Clin Epigenetics
. 2022 Nov;
14(1):142.
PMID: 36329530
Background: Arterial hypertension represents a worldwide health burden and a major risk factor for cardiovascular morbidity and mortality. Hypertension can be primary (primary hypertension, PHT), or secondary to endocrine disorders...
3.
Reel P, Reel S, van Kralingen J, Langton K, Lang K, Erlic Z, et al.
EBioMedicine
. 2022 Sep;
84:104276.
PMID: 36179553
Background: Arterial hypertension is a major cardiovascular risk factor. Identification of secondary hypertension in its various forms is key to preventing and targeting treatment of cardiovascular complications. Simplified diagnostic tests...
4.
Moudio S, Willis A, Pytka K, Abulkassim R, Brett R, Webster J, et al.
Psychopharmacology (Berl)
. 2021 Dec;
239(1):229-242.
PMID: 34888704
Rationale: Major depressive disorder (MDD) is a leading cause of disability worldwide but currently prescribed treatments do not adequately ameliorate the disorder in a significant portion of patients. Hence, a...
5.
MacKenzie S, Saunders H, van Kralingen J, Robertson S, Riddell A, Zennaro M, et al.
Cancers (Basel)
. 2021 Nov;
13(21).
PMID: 34771478
Primary aldosteronism (PA) is a common and highly treatable condition, usually resulting from adrenocortical tumorous growth or hyperplasia. PA is currently underdiagnosed owing to its complex and protracted diagnostic procedures....
6.
MacKenzie S, van Kralingen J, Davies E
Vitam Horm
. 2019 Jan;
109:241-263.
PMID: 30678858
Secretion of the major mineralocorticoid aldosterone from the adrenal cortex is a tightly-regulated process enabling this hormone to regulate sodium homeostasis and thereby contribute to blood pressure control. The circulating...
7.
McCarroll C, He W, Foote K, Bradley A, McGlynn K, Vidler F, et al.
Circulation
. 2017 Oct;
137(1):57-70.
PMID: 29030345
Background: Myocardial infarction (MI) is a leading cause of heart failure and death worldwide. Preservation of contractile function and protection against adverse changes in ventricular architecture (cardiac remodeling) are key...
8.
Robertson S, Diver L, Alvarez-Madrazo S, Livie C, Ejaz A, Fraser R, et al.
Int J Endocrinol
. 2017 Aug;
2017:2021903.
PMID: 28852406
The loss of normal regulation of corticosteroid secretion is important in the development of cardiovascular disease. We previously showed that microRNAs regulate the terminal stages of corticosteroid biosynthesis. Here, we...
9.
MacKenzie S, Freel E, Connell J, Fraser R, Davies E
Int J Mol Sci
. 2017 Mar;
18(3).
PMID: 28272372
The majority of genes contributing to the heritable component of blood pressure remain unidentified, but there is substantial evidence to suggest that common polymorphisms at loci involved in the biosynthesis...
10.
MacKenzie S, Davies E, Alvarez-Madrazo S
Methods Mol Biol
. 2017 Jan;
1527:139-150.
PMID: 28116713
The aldosterone synthase (CYP11B2) and 11β-hydroxylase (CYP11B1) enzymes are known to be important players in the development of hypertension. Sequencing of the CYP11B2 and CYP11B1 genes and quantification of their...