Scott L Crick
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Explore the profile of Scott L Crick including associated specialties, affiliations and a list of published articles.
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13
Citations
1047
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Recent Articles
1.
Qavi A, Jiang Q, Aman M, Vu H, Zetlin L, Dye J, et al.
ACS Infect Dis
. 2023 Dec;
10(1):57-63.
PMID: 38048277
Filoviruses comprise a family of single-stranded, negative-sense RNA viruses with a significant impact on human health. Given the risk for disease outbreaks, as highlighted by the recent outbreaks across Africa,...
2.
Qavi A, Wu C, Lloyd M, Zaman M, Luan J, Ballman C, et al.
ACS Infect Dis
. 2022 Jul;
8(8):1468-1479.
PMID: 35867632
Serological testing for acute infection or prior exposure is critical for patient management and coordination of public health decisions during outbreaks. Current methods have several limitations, including variable performance, relatively...
3.
Posey A, Ruff K, Harmon T, Crick S, Li A, Diamond M, et al.
J Biol Chem
. 2018 Jan;
293(10):3734-3746.
PMID: 29358329
Huntingtin N-terminal fragments (Htt-NTFs) with expanded polyglutamine tracts form a range of neurotoxic aggregates that are associated with Huntington's disease. Here, we show that aggregation of Htt-NTFs, irrespective of polyglutamine...
4.
Crick S, Ruff K, Garai K, Frieden C, Pappu R
Proc Natl Acad Sci U S A
. 2013 Nov;
110(50):20075-80.
PMID: 24282292
Huntington disease is caused by mutational expansion of the CAG trinucleotide within exon 1 of the huntingtin (Htt) gene. Exon 1 spanning N-terminal fragments (NTFs) of the Htt protein result...
5.
Shu Q, Crick S, Pinkner J, Ford B, Hultgren S, Frieden C
Proc Natl Acad Sci U S A
. 2012 Apr;
109(17):6502-7.
PMID: 22493266
Curli are extracellular proteinaceous functional amyloid aggregates produced by Escherichia coli, Salmonella spp., and other enteric bacteria. Curli mediate host cell adhesion and invasion and play a critical role in...
6.
Das R, Crick S, Pappu R
J Mol Biol
. 2012 Jan;
416(2):287-99.
PMID: 22226835
Basic region leucine zippers (bZIPs) are modular transcription factors that play key roles in eukaryotic gene regulation. The basic regions of bZIPs (bZIP-bRs) are necessary and sufficient for DNA binding...
7.
Mustafi S, Garai K, Crick S, Baban B, Frieden C
Biochem Biophys Res Commun
. 2010 Jun;
397(3):509-12.
PMID: 20515649
Abeta peptides aggregate to form insoluble and neurotoxic fibrils associated with Alzheimer's disease. Inhibition of the aggregation has been the subject of numerous studies. Here we describe a novel, substoichiometric...
8.
Mao A, Crick S, Vitalis A, Chicoine C, Pappu R
Proc Natl Acad Sci U S A
. 2010 Apr;
107(18):8183-8.
PMID: 20404210
Intrinsically disordered proteins (IDPs) adopt heterogeneous ensembles of conformations under physiological conditions. Understanding the relationship between amino acid sequence and conformational ensembles of IDPs can help clarify the role of...
9.
Williamson T, Vitalis A, Crick S, Pappu R
J Mol Biol
. 2009 Dec;
396(5):1295-309.
PMID: 20026071
Polyglutamine expansions within different proteins are associated with nine different neurodegenerative diseases. There is growing interest in understanding the roles of flanking sequences from disease-relevant proteins in the intrinsic conformational...
10.
Hu X, Crick S, Bu G, Frieden C, Pappu R, Lee J
Proc Natl Acad Sci U S A
. 2009 Nov;
106(48):20324-9.
PMID: 19910533
One of the neuropathological hallmarks of Alzheimer's disease (AD) is the amyloid plaque, primarily composed of aggregated amyloid-beta (Abeta) peptide. In vitro, Abeta(1-42), the major alloform of Abeta found in...