Gaya K Amarasinghe
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Explore the profile of Gaya K Amarasinghe including associated specialties, affiliations and a list of published articles.
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4582
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Recent Articles
1.
Frey Z, Price D, Connors K, Rush R, Brown G, Sterling C, et al.
bioRxiv
. 2024 Nov;
PMID: 39574651
Jamestown Canyon virus (JCV) is a bunyavirus and arbovirus responsible for neuroinvasive disease in the United States. Little is known about JCV pathogenesis, and no host factors required for cellular...
2.
Connors K, Pedlow M, Frey Z, McGaughey J, Amarasinghe G, Duprex W, et al.
bioRxiv
. 2024 Oct;
PMID: 39416126
Oropouche fever is a re-emerging global viral threat caused by infection with Oropouche orthobunyavirus (OROV). While disease is generally self-limiting, historical and recent reports of neurologic involvement highlight the importance...
3.
Tomaszewski K, Blanchard M, Olaniyi R, Brenton H, Hayes S, Fatma F, et al.
Nat Commun
. 2024 Oct;
15(1):8702.
PMID: 39379345
Staphylococcus aureus remains a leading global cause of bacterial infection-associated mortality and has eluded prior vaccine development efforts. S. aureus α-toxin (Hla) is an essential virulence factor in disease, impairing...
4.
Carlson R, Patten J, Stefanakis G, Soong B, Radhakrishnan A, Singh A, et al.
bioRxiv
. 2024 Apr;
PMID: 38617272
Ebola virus (EBOV) is a high-consequence filovirus that gives rise to frequent epidemics with high case fatality rates and few therapeutic options. Here, we applied image-based screening of a genome-wide...
5.
Vogel O, Forwood J, Leung D, Amarasinghe G, Basler C
Cells
. 2024 Jan;
13(1).
PMID: 38201275
Cellular nucleocytoplasmic trafficking is mediated by the importin family of nuclear transport proteins. The well-characterized importin alpha (IMPA) and importin beta (IMPB) nuclear import pathway plays a crucial role in...
6.
Cheng S, Lau J, Tsang L, Leung K, Lee C, Hachim A, et al.
J Clin Virol
. 2023 Dec;
170:105621.
PMID: 38056114
Background: Natural SARS-CoV-2 infection may elicit antibodies to a range of viral proteins including non-structural protein ORF8. RNA, adenovirus vectored and sub-unit vaccines expressing SARS-CoV-2 spike would be only expected...
7.
Qavi A, Jiang Q, Aman M, Vu H, Zetlin L, Dye J, et al.
ACS Infect Dis
. 2023 Dec;
10(1):57-63.
PMID: 38048277
Filoviruses comprise a family of single-stranded, negative-sense RNA viruses with a significant impact on human health. Given the risk for disease outbreaks, as highlighted by the recent outbreaks across Africa,...
8.
Lau J, Cheng S, Leung K, Lee C, Hachim A, Tsang L, et al.
Nat Med
. 2023 Oct;
30(1):305.
PMID: 37875568
No abstract available.
9.
Ganaie S, Leung D, Hartman A, Amarasinghe G
Adv Virus Res
. 2023 Oct;
117():121-136.
PMID: 37832991
Rift Valley Fever Virus (RVFV) is a negative sense segmented RNA virus that can cause severe hemorrhagic fever. The tri-segmented virus genome encodes for six (6) multifunctional proteins that engage...
10.
Wu C, Wagner N, Moyle A, Feng A, Sharma N, Stubbs S, et al.
J Mol Biol
. 2023 Aug;
435(20):168241.
PMID: 37598728
Viral inclusion bodies (IBs) are potential sites of viral replication and assembly. How viral IBs form remains poorly defined. Here we describe a combined biophysical and cellular approach to identify...