Scott H Soderling
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Explore the profile of Scott H Soderling including associated specialties, affiliations and a list of published articles.
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51
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Recent Articles
1.
Bhat S, Palepu K, Hong L, Mao J, Ye T, Iyer R, et al.
Sci Adv
. 2025 Jan;
11(4):eadr8638.
PMID: 39841846
Designing binders to target undruggable proteins presents a formidable challenge in drug discovery. In this work, we provide an algorithmic framework to design short, target-binding linear peptides, requiring only the...
2.
Hossain K, Erata E, Schiapparelli L, Soderling S
eNeuro
. 2024 Dec;
PMID: 39694826
Epilepsy Aphasia Syndrome (EAS) is a spectrum of childhood disorders that exhibit complex co-morbidities that include epilepsy and the emergence of cognitive and language disorders. CNKSR2 is an X-linked gene...
3.
Wang S, Baumert R, Sejourne G, Bindu D, Dimond K, Sakers K, et al.
bioRxiv
. 2024 Sep;
PMID: 39253496
Astrocytes, a major glial cell type of the brain, regulate synapse numbers and function. However, whether astrocyte dysfunction can cause synaptic pathologies in neurological disorders such as Parkinson's Disease (PD)...
4.
Gao Y, Shonai D, Trn M, Zhao J, Soderblom E, Garcia-Moreno S, et al.
Nat Commun
. 2024 Aug;
15(1):6801.
PMID: 39122707
One of the main drivers of autism spectrum disorder is risk alleles within hundreds of genes, which may interact within shared but unknown protein complexes. Here we develop a scalable...
5.
Bhat S, Palepu K, Hong L, Mao J, Ye T, Iyer R, et al.
bioRxiv
. 2024 Aug;
PMID: 39091799
Designing binders to target undruggable proteins presents a formidable challenge in drug discovery, requiring innovative approaches to overcome the lack of putative binding sites. Recently, generative models have been trained...
6.
Kim J, Bustamante E, Sotonyi P, Maxwell N, Parameswaran P, Kent J, et al.
Elife
. 2024 Jul;
13.
PMID: 39046788
One of the most extensively studied members of the Ras superfamily of small GTPases, Rac1 is an intracellular signal transducer that remodels actin and phosphorylation signaling networks. Previous studies have...
7.
Kim J, Bustamante E, Sotonyi P, Maxwell N, Parameswaran P, Kent J, et al.
bioRxiv
. 2024 Apr;
PMID: 38562715
One of the most extensively studied members of the Ras superfamily of small GTPases, Rac1 is an intracellular signal transducer that remodels actin and phosphorylation signaling networks. Previous studies have...
8.
Loukil A, Ebright E, Uezu A, Gao Y, Soderling S, Goetz S
bioRxiv
. 2024 Jan;
PMID: 38187761
Primary cilia are conserved sensory hubs essential for signaling transduction and embryonic development. Ciliary dysfunction causes a variety of developmental syndromes with neurological features and cognitive impairment, whose basis mostly...
9.
Ulloa Severino F, Lawal O, Sakers K, Wang S, Kim N, Friedman A, et al.
Nat Commun
. 2023 Sep;
14(1):5522.
PMID: 37684234
Synaptogenesis is essential for circuit development; however, it is unknown whether it is critical for the establishment and performance of goal-directed voluntary behaviors. Here, we show that operant conditioning via...
10.
Hisey E, Purkey A, Gao Y, Hossain K, Soderling S, Ressler K
Biol Psychiatry
. 2023 Mar;
94(3):239-248.
PMID: 36925415
Background: The ability to correctly associate cues and contexts with threat is critical for survival, and the inability to do so can result in threat-related disorders such as posttraumatic stress...