Scott B Vafai
Overview
Explore the profile of Scott B Vafai including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
14
Citations
2082
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Lee R, Mazzola A, Braun M, Platt C, Vafai S, Kathiresan S, et al.
Circulation
. 2022 Oct;
147(3):242-253.
PMID: 36314243
Background: VERVE-101 is an investigational in vivo CRISPR base-editing medicine designed to alter a single DNA base in the gene, permanently turn off hepatic protein production, and thereby durably lower...
2.
To T, Cuadros A, Shah H, Hung W, Li Y, Kim S, et al.
Cell
. 2019 Nov;
179(5):1222-1238.e17.
PMID: 31730859
Mitochondrial dysfunction is associated with a spectrum of human conditions, ranging from rare, inborn errors of metabolism to the aging process. To identify pathways that modify mitochondrial dysfunction, we performed...
3.
Kraft G, Vrba A, Scott M, Allen E, Edgerton D, Williams P, et al.
Diabetes
. 2019 Apr;
68(6):1143-1155.
PMID: 30936143
This study assessed the effectiveness of surgical sympathetic denervation of the common hepatic artery (CHADN) in improving glucose tolerance. CHADN eliminated norepinephrine content in the liver and partially decreased it...
4.
Vafai S, Mevers E, Higgins K, Fomina Y, Zhang J, Mandinova A, et al.
PLoS One
. 2016 Sep;
11(9):e0162686.
PMID: 27622560
Deficiency of mitochondrial complex I is encountered in both rare and common diseases, but we have limited therapeutic options to treat this lesion to the oxidative phosphorylation system (OXPHOS). Idebenone...
5.
Robert Bao X, Ong S, Goldberger O, Peng J, Sharma R, Thompson D, et al.
Elife
. 2016 Jun;
5.
PMID: 27307216
Mitochondrial dysfunction is associated with a spectrum of human disorders, ranging from rare, inborn errors of metabolism to common, age-associated diseases such as neurodegeneration. How these lesions give rise to...
6.
Lennerz B, Vafai S, Delaney N, Clish C, Deik A, Pierce K, et al.
Mol Genet Metab
. 2014 Dec;
114(1):73-9.
PMID: 25497115
Sodium benzoate is a widely used preservative found in many foods and soft drinks. It is metabolized within mitochondria to produce hippurate, which is then cleared by the kidneys. We...
7.
8.
Vafai S, Mootha V
Nature
. 2012 Nov;
491(7424):374-83.
PMID: 23151580
Much of our current knowledge about mitochondria has come from studying patients who have respiratory chain disorders. These disorders comprise a large collection of individually rare syndromes, each presenting in...
9.
Lieber D, Vafai S, Horton L, Slate N, Liu S, Borowsky M, et al.
BMC Med Genet
. 2012 Jan;
13:3.
PMID: 22226368
Background: Mitochondrial diseases comprise a diverse set of clinical disorders that affect multiple organ systems with varying severity and age of onset. Due to their clinical and genetic heterogeneity, these...
10.
Bhalla K, Hwang B, Dewi R, Ou L, Twaddel W, Fang H, et al.
Cancer Res
. 2011 Sep;
71(21):6888-98.
PMID: 21914785
Despite the role of aerobic glycolysis in cancer, recent studies highlight the importance of the mitochondria and biosynthetic pathways as well. PPARγ coactivator 1α (PGC1α) is a key transcriptional regulator...