Scott A Johnson
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Explore the profile of Scott A Johnson including associated specialties, affiliations and a list of published articles.
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52
Citations
1454
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Recent Articles
11.
Brown Z, Mapelli C, Farasat I, Shoultz A, Johnson S, Orvieto F, et al.
J Org Chem
. 2019 Oct;
85(3):1466-1475.
PMID: 31660743
The Myc transcription factor represents an "undruggable" target of high biological interest due to its central role in various cancers. An abbreviated form of the c-Myc protein, called Omomyc, consists...
12.
Gunaydin H, Altman M, Ellis J, Fuller P, Johnson S, Lahue B, et al.
ACS Med Chem Lett
. 2018 Jun;
9(6):528-533.
PMID: 29937977
Preclinical optimization of compounds toward viable drug candidates requires an integrated understanding of properties that impact predictions of the clinically efficacious dose. The importance of optimizing half-life, unbound clearance, and...
13.
Turner N, Johnson S, Foster L, Badylak S
J Biomed Mater Res B Appl Biomater
. 2017 Aug;
106(5):1698-1711.
PMID: 28851086
The outcome of peripheral nerve repair following transection is influenced by a number of factors but almost all approaches require anastomosis of the nerve using technically demanding microsurgical procedures. However,...
14.
Brown F, Kopti F, Chang C, Johnson S, Glick M, Waller C
AAPS J
. 2017 Aug;
19(5):1255-1263.
PMID: 28770387
Merck & Co., Inc., Kenilworth, NJ, USA, is undergoing a transformation in the way that it prosecutes R&D programs. Through the adoption of a "model-driven" culture, enhanced R&D productivity is...
15.
Fercana G, Yerneni S, Billaud M, Hill J, VanRyzin P, Richards T, et al.
Biomaterials
. 2017 Feb;
123:142-154.
PMID: 28167392
Extracellular matrix (ECM)-derived bioscaffolds have been shown to elicit tissue repair through retention of bioactive signals. Given that the adventitia of large blood vessels is a richly vascularized microenvironment, we...
16.
Brown F, Sherer E, Johnson S, Holloway M, Sherborne B
J Comput Aided Mol Des
. 2016 Nov;
31(3):255-266.
PMID: 27878643
On October 5, 1981, Fortune magazine published a cover article entitled the "Next Industrial Revolution: Designing Drugs by Computer at Merck". With a 40+ year investment, we have been in...
17.
Allen S, Parthasarathy G, Darke P, Diehl R, Ford R, Hall D, et al.
J Biol Chem
. 2015 Jul;
290(33):20360-73.
PMID: 26134571
G-protein-coupled receptor (GPCR) kinases (GRKs) bind to and phosphorylate GPCRs, initiating the process of GPCR desensitization and internalization. GRK4 is implicated in the regulation of blood pressure, and three GRK4...
18.
Johnson S
Int J Emerg Ment Health
. 2014 Oct;
16(1):259-69.
PMID: 25345240
Sex offenders and violent offenders in general that were intoxicated at the time of their offense often claim that they were too intoxicated to know 1) what they were doing...
19.
Carey L, Dearth C, Johnson S, Londono R, Medberry C, Daly K, et al.
Biomaterials
. 2014 Jul;
35(29):8297-304.
PMID: 24997479
Biologic scaffold materials are used for repair and reconstruction of injured or missing tissues. Such materials are often composed of allogeneic or xenogeneic extracellular matrix (ECM) manufactured by decellularization of...
20.
Faulk D, Johnson S, Zhang L, Badylak S
J Cell Physiol
. 2013 Dec;
229(8):984-9.
PMID: 24347365
End-stage organ failure is a devastating problem with limited therapeutic options. The definitive treatment is orthotropic transplantation, however, there exists a severe shortage of viable donor organs, and this shortage...