Sava Sakadzic
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Explore the profile of Sava Sakadzic including associated specialties, affiliations and a list of published articles.
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117
Citations
3196
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Recent Articles
1.
Lai J, Qin T, Boas D, Sakadzic S, Ayata C, Chung D
Neurology
. 2025 Feb;
102(7_supplement_1):3357.
PMID: 39977922
Objective: To investigate the impact of tribromoethanol, isoflurane, and ketamine/xylazine on neuronally- and hemodynamically-based functional connectivity. Background: Resting-state functional connectivity (RSFC) captures correlated signals among brain regions while at rest....
2.
Hou S, Yang J, Kwon Y, Pian Q, Tang Y, Dauphinais C, et al.
bioRxiv
. 2025 Feb;
PMID: 39896645
Multiphoton microscopy serves as an essential tool for high-resolution imaging of the living mouse brain. To facilitate optical access to the brain during imaging, the cranial window surgery is commonly...
3.
Aykan S, Lai J, Sugimoto K, Aykan O, Fung W, Ho D, et al.
Stroke
. 2025 Jan;
PMID: 39882613
Cerebral autosomal-dominant arteriopathy, subcortical infarcts, and leukoencephalopathy (CADASIL) is the most prevalent monogenic inherited cause of cerebral small-vessel disease. Despite its prevalence, there is currently no proven therapy to prevent...
4.
Ishikawa H, Hoshino T, Hamanaka G, Mandeville E, Guo S, Kimura S, et al.
iScience
. 2025 Jan;
28(1):111556.
PMID: 39845418
The corpus callosum, a major white matter region central to cognitive function, is vulnerable to aging. Using zeitgeber time (ZT) aligned with environmental light/dark cycles, we investigated temporal gene expression...
5.
Pian Q, Li B, Sencan-Egilmez I, Cheng X, Dubb J, Huang X, et al.
Biomed Opt Express
. 2025 Jan;
16(1):159-176.
PMID: 39816157
Two-photon phosphorescence lifetime microscopy has been a key tool for studying cerebral oxygenation in mice. However, the accuracy of the partial pressure of oxygen (pO) measurements is affected by out-of-focus...
6.
Sugimoto K, Chung D, Fischer P, Takizawa T, Qin T, Yaseen M, et al.
Stroke
. 2024 Sep;
55(10):2502-2509.
PMID: 39234742
Background: Functional activation of the focal ischemic brain has been reported to improve outcomes by augmenting collateral blood flow. However, functional activation also increases metabolic demand and might thereby worsen...
7.
Gutierrez-Jimenez E, Rasmussen P, Mikkelsen I, Kura S, Fruekilde S, Hansen B, et al.
bioRxiv
. 2024 Sep;
PMID: 39229198
Introduction: Disturbances in microvascular flow dynamics are hypothesized to precede the symptomatic phase of Alzheimer's disease (AD). However, evidence in presymptomatic AD remains elusive, underscoring the need for therapies targeting...
8.
Doran P, Fomin-Thunemann N, Tang R, Balog D, Zimmerman B, Kilic K, et al.
Neurophotonics
. 2024 Jun;
11(3):034310.
PMID: 38881627
Significance: Widefield microscopy of the entire dorsal part of mouse cerebral cortex enables large-scale ("mesoscopic") imaging of different aspects of neuronal activity with spectrally compatible fluorescent indicators as well as...
9.
Wang X, Anastasio M, Zhang H, Sakadzic S, Hu S, Gao L
J Biomed Opt
. 2024 Jun;
29(Suppl 1):S11500.
PMID: 38846410
The editorial concludes the JBO Special Issue Honoring Lihong V. Wang, outlining Prof. Wang's salient contributions to advancing the field of biomedical optics.
10.
Doran P, Fomin-Thunemann N, Tang R, Balog D, Zimmerman B, Kilic K, et al.
bioRxiv
. 2023 Nov;
PMID: 37986755
Significance: Widefield microscopy of the entire dorsal part of mouse cerebral cortex enables large-scale (mesoscopic) imaging of neuronal activity with fluorescent indicators as well as hemodynamics via oxy- and deoxyhemoglobin...