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Buyin Fu

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Articles 19
Citations 290
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Recent Articles
1.
Pian Q, Li B, Sencan-Egilmez I, Cheng X, Dubb J, Huang X, et al.
Biomed Opt Express . 2025 Jan; 16(1):159-176. PMID: 39816157
Two-photon phosphorescence lifetime microscopy has been a key tool for studying cerebral oxygenation in mice. However, the accuracy of the partial pressure of oxygen (pO) measurements is affected by out-of-focus...
2.
Pian Q, Alfadhel M, Tang J, Lee G, Li B, Fu B, et al.
J Biomed Opt . 2023 Jul; 28(7):076003. PMID: 37484973
Significance: The accurate large-scale mapping of cerebral microvascular blood flow velocity is crucial for a better understanding of cerebral blood flow (CBF) regulation. Although optical imaging techniques enable both high-resolution...
3.
Shin P, Pian Q, Ishikawa H, Hamanaka G, Mandeville E, Guo S, et al.
Elife . 2023 Jul; 12. PMID: 37402178
Aging is a major risk factor for cognitive impairment. Aerobic exercise benefits brain function and may promote cognitive health in older adults. However, underlying biological mechanisms across cerebral gray and...
4.
Li B, Leng J, Sencan-Egilmez I, Takase H, Alfadhel M, Fu B, et al.
Neurophotonics . 2023 Jun; 10(3):035001. PMID: 37323511
Significance: It has been hypothesized that abnormal microcirculation in the retina might predict the risk of ischemic damages in the brain. Direct comparison between the retinal and the cerebral microcirculation...
5.
Li B, Yabluchanskiy A, Tarantini S, Rao Allu S, Sencan-Egilmez I, Leng J, et al.
Geroscience . 2023 Feb; 45(3):1491-1510. PMID: 36792820
Whole-brain irradiation (WBI, also known as whole-brain radiation therapy) is a mainstay treatment modality for patients with multiple brain metastases. It is also used as a prophylactic treatment for microscopic...
6.
Liu C, Chisholm A, Fu B, Su C, Sencan I, Sakadzic S, et al.
Biomed Opt Express . 2021 Aug; 12(7):4192-4206. PMID: 34457408
Time-domain measurements for fluorescence lifetime imaging microscopy (FLIM) and phosphorescence lifetime imaging microscopy (PLIM) are conventionally computed by nonlinear curve fitting techniques to model the time-resolved profiles as mono- or...
7.
Oka F, Sadeghian H, Yaseen M, Fu B, Kura S, Qin T, et al.
Brain . 2021 Jul; 145(1):194-207. PMID: 34245240
Spreading depolarizations are highly prevalent and spatiotemporally punctuated events worsening the outcome of brain injury. Trigger factors are poorly understood but may be linked to sudden worsening in supply-demand mismatch...
8.
Sencan I, Esipova T, Kilic K, Li B, Desjardins M, Yaseen M, et al.
J Cereb Blood Flow Metab . 2020 Jun; 42(3):510-525. PMID: 32515672
The cerebral cortex has a number of conserved morphological and functional characteristics across brain regions and species. Among them, the laminar differences in microvascular density and mitochondrial cytochrome c oxidase...
9.
Li B, Esipova T, Sencan I, Kilic K, Fu B, Desjardins M, et al.
Elife . 2019 Jul; 8. PMID: 31305237
Our understanding of how capillary blood flow and oxygen distribute across cortical layers to meet the local metabolic demand is incomplete. We addressed this question by using two-photon imaging of...
10.
Li B, Ohtomo R, Thunemann M, Adams S, Yang J, Fu B, et al.
J Cereb Blood Flow Metab . 2019 Mar; 40(3):501-512. PMID: 30829101
Despite the importance of understanding the regulation of microvascular blood flow in white matter, no data on subcortical capillary blood flow parameters are available, largely due to the lack of...