Sava Sakadzic
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Explore the profile of Sava Sakadzic including associated specialties, affiliations and a list of published articles.
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117
Citations
3196
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Recent Articles
11.
Tahir W, Kura S, Zhu J, Cheng X, Damseh R, Tadesse F, et al.
BME Front
. 2023 Oct;
2020:8620932.
PMID: 37849965
. Segmentation of blood vessels from two-photon microscopy (2PM) angiograms of brains has important applications in hemodynamic analysis and disease diagnosis. Here, we develop a generalizable deep learning technique for...
12.
Fischer P, Tamim I, Sugimoto K, Morais A, Imai T, Takizawa T, et al.
Stroke
. 2023 Aug;
54(10):2640-2651.
PMID: 37610105
Background: Spreading depolarizations (SDs) occur in all types of brain injury and may be associated with detrimental effects in ischemic stroke and subarachnoid hemorrhage. While rapid hematoma growth during intracerebral...
13.
Pian Q, Alfadhel M, Tang J, Lee G, Li B, Fu B, et al.
J Biomed Opt
. 2023 Jul;
28(7):076003.
PMID: 37484973
Significance: The accurate large-scale mapping of cerebral microvascular blood flow velocity is crucial for a better understanding of cerebral blood flow (CBF) regulation. Although optical imaging techniques enable both high-resolution...
14.
Shin P, Pian Q, Ishikawa H, Hamanaka G, Mandeville E, Guo S, et al.
Elife
. 2023 Jul;
12.
PMID: 37402178
Aging is a major risk factor for cognitive impairment. Aerobic exercise benefits brain function and may promote cognitive health in older adults. However, underlying biological mechanisms across cerebral gray and...
15.
Li B, Leng J, Sencan-Egilmez I, Takase H, Alfadhel M, Fu B, et al.
Neurophotonics
. 2023 Jun;
10(3):035001.
PMID: 37323511
Significance: It has been hypothesized that abnormal microcirculation in the retina might predict the risk of ischemic damages in the brain. Direct comparison between the retinal and the cerebral microcirculation...
16.
Sugimoto K, Yang J, Fischer P, Takizawa T, Mulder I, Qin T, et al.
Stroke
. 2023 Mar;
54(4):1110-1119.
PMID: 36876481
Background: Spreading depolarizations (SDs) are believed to contribute to injury progression and worsen outcomes in focal cerebral ischemia because exogenously induced SDs have been associated with enlarged infarct volumes. However,...
17.
Shin P, Pian Q, Ishikawa H, Hamanaka G, Mandeville E, Shuzhen G, et al.
bioRxiv
. 2023 Feb;
PMID: 36824939
Aging is a major risk factor for cognitive impairment. Aerobic exercise benefits brain function and may promote cognitive health in older adults. However, underlying biological mechanisms across cerebral gray and...
18.
Li B, Yabluchanskiy A, Tarantini S, Rao Allu S, Sencan-Egilmez I, Leng J, et al.
Geroscience
. 2023 Feb;
45(3):1491-1510.
PMID: 36792820
Whole-brain irradiation (WBI, also known as whole-brain radiation therapy) is a mainstay treatment modality for patients with multiple brain metastases. It is also used as a prophylactic treatment for microscopic...
19.
Machler P, Fomin-Thunemann N, Thunemann M, Saetra M, Desjardins M, Kilic K, et al.
PLoS Biol
. 2022 Oct;
20(10):e3001440.
PMID: 36301995
The cerebral cortex is organized in cortical layers that differ in their cellular density, composition, and wiring. Cortical laminar architecture is also readily revealed by staining for cytochrome oxidase-the last...
20.
Aykan S, Xie H, Zheng Y, Chung D, Kura S, Lai J, et al.
Stroke
. 2022 Jun;
53(7):2369-2376.
PMID: 35656825
Background: Subcortical white matter lesions are exceedingly common in cerebral small vessel disease and lead to significant cumulative disability without an available treatment. Here, we tested a rho-kinase inhibitor on...