Saulius Sumanas
Overview
Explore the profile of Saulius Sumanas including associated specialties, affiliations and a list of published articles.
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Articles
48
Citations
1075
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0
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Recent Articles
1.
Laverde V, Loges L, Sumanas S
Biol Open
. 2025 Mar;
PMID: 40079219
During embryonic development vascular endothelial and hematopoietic cells are thought to originate from a common precursor, the hemangioblast. An evolutionarily conserved ETS transcription factor FLI1 has been previously implicated in...
2.
Ming Z, Liu F, Moran H, Lalonde R, Adams M, Restrepo N, et al.
bioRxiv
. 2024 Dec;
PMID: 39677658
Background: The ability to generate endogenous Cre recombinase drivers using CRISPR-Cas9 knock-in technology allows lineage tracing, cell type specific gene studies, and validation of inferred developmental trajectories from phenotypic and...
3.
Yrigoin K, Bernard K, Castano M, Cleaver O, Sumanas S, Davis G
Front Cell Dev Biol
. 2024 Nov;
12:1465806.
PMID: 39544367
In this study, we identify and characterize new molecular determinants that optimize human capillary tube network assembly. Our lab has previously reported a novel, serum free-defined 3D co-culture model using...
4.
Marsili L, Kauffman M, Rufin Florat D, Zaidi A, Botsford V, Sharma J, et al.
Parkinsonism Relat Disord
. 2024 Nov;
117:105898.
PMID: 39492172
We describe an elderly woman meeting criteria for vascular parkinsonism/dementia associated with a likely pathogenic variant in the COL22A1 gene, supported by functional experiments in a zebrafish model. We suggest...
5.
Gurung S, Restrepo N, Anand S, Sittaramane V, Sumanas S
Dev Dyn
. 2024 Feb;
253(8):750-770.
PMID: 38340011
Background: During neurogenesis, growing axons must navigate through the complex extracellular environment and make correct synaptic connections for the proper functioning of neural circuits. The mechanisms underlying the formation of...
6.
Gurung S, Restrepo N, Sumanas S
Cell Rep
. 2024 Feb;
43(2):113736.
PMID: 38308842
Previous studies have suggested that the endocardium contributes to hematopoiesis in murine embryos, although definitive evidence to demonstrate the hematopoietic potential of the endocardium is still missing. Here, we use...
7.
Schumacher J, Wright Z, Rufin Florat D, Anand S, Dasyani M, Batta S, et al.
PLoS Genet
. 2024 Jan;
20(1):e1010851.
PMID: 38190417
Blood vessels in different vascular beds vary in size, which is essential for their function and fluid flow along the vascular network. Molecular mechanisms involved in the formation of a...
8.
Schumacher J, Wright Z, Rufin Florat D, Anand S, Dasyani M, Klimkaite L, et al.
bioRxiv
. 2023 Jul;
PMID: 37461480
Blood vessels in different vascular beds vary in lumen diameter, which is essential for their function and fluid flow along the vascular network. Molecular mechanisms involved in the formation of...
9.
Gurung S, Restrepo N, Chestnut B, Klimkaite L, Sumanas S
Sci Rep
. 2022 Jul;
12(1):13065.
PMID: 35906287
Vascular endothelial cells exhibit substantial phenotypic and transcriptional heterogeneity which is established during early embryogenesis. However, the molecular mechanisms involved in establishing endothelial cell diversity are still not well understood....
10.
Metikala S, Warkala M, Casie Chetty S, Chestnut B, Rufin Florat D, Plender E, et al.
Dev Cell
. 2022 Mar;
57(6):767-782.e6.
PMID: 35276066
During embryogenesis, the initial vascular network forms by the process of vasculogenesis, or the specification of vascular progenitors de novo. In contrast, the majority of later-forming vessels arise by angiogenesis...