Satpal Virdee
Overview
Explore the profile of Satpal Virdee including associated specialties, affiliations and a list of published articles.
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28
Citations
1119
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Recent Articles
1.
Barnsby-Greer L, Mabbitt P, Dery M, Squair D, Wood N, Lamoliatte F, et al.
Nat Struct Mol Biol
. 2024 Jan;
31(2):351-363.
PMID: 38182926
UBR4 is a 574 kDa E3 ligase (E3) of the N-degron pathway with roles in neurodevelopment, age-associated muscular atrophy and cancer. The catalytic module that carries out ubiquitin (Ub) transfer...
2.
Squair D, Virdee S
Nat Chem Biol
. 2022 Jul;
18(8):802-811.
PMID: 35896829
The ubiquitin system has become synonymous with the modification of lysine residues. However, the substrate scope and diversity of the conjugation machinery have been underappreciated, bringing us to an epoch...
3.
Bustos F, Mathur S, Espejo-Serrano C, Toth R, Hastie C, Virdee S, et al.
Life Sci Alliance
. 2022 Jun;
5(11).
PMID: 35764390
Ubiquitylation enzymes are involved in all aspects of eukaryotic biology and are frequently disrupted in disease. One example is the E3 ubiquitin ligase RNF12/RLIM, which is mutated in the developmental...
4.
Virdee S
Neural Regen Res
. 2022 May;
17(11):2347-2350.
PMID: 35535869
The degeneration of nerve fibres following injury was first described by Augustus Waller over 170 years ago. Initially assumed to be a passive process, it is now evident that axons...
5.
Spear L, Huang Y, Chen J, Nodling A, Virdee S, Tsai Y
J Mol Biol
. 2022 Mar;
434(8):167524.
PMID: 35248542
A general approach for the rapid and selective inhibition of enzymes in cells using a common tool compound would be of great value for research and therapeutic development. We previously...
6.
De Cesare V, Carbajo Lopez D, Mabbitt P, Fletcher A, Soetens M, Antico O, et al.
Proc Natl Acad Sci U S A
. 2021 Jan;
118(4).
PMID: 33479176
The reversibility of ubiquitination by the action of deubiquitinating enzymes (DUBs) serves as an important regulatory layer within the ubiquitin system. Approximately 100 DUBs are encoded by the human genome,...
7.
Mabbitt P, Loreto A, Dery M, Fletcher A, Stanley M, Pao K, et al.
Nat Chem Biol
. 2020 Aug;
16(11):1227-1236.
PMID: 32747811
MYCBP2 is a ubiquitin (Ub) E3 ligase (E3) that is essential for neurodevelopment and regulates axon maintenance. MYCBP2 transfers Ub to nonlysine substrates via a newly discovered RING-Cys-Relay (RCR) mechanism,...
8.
Mathur S, Fletcher A, Branigan E, Hay R, Virdee S
Cell Chem Biol
. 2019 Dec;
27(1):74-82.e6.
PMID: 31859248
Activity-based protein profiling is an invaluable technique for studying enzyme biology and facilitating the development of therapeutics. Ubiquitin E3 ligases (E3s) are one of the largest enzyme families and regulate...
9.
Pao K, Wood N, Knebel A, Rafie K, Stanley M, Mabbitt P, et al.
Nature
. 2018 Apr;
556(7701):381-385.
PMID: 29643511
Ubiquitination is initiated by transfer of ubiquitin (Ub) from a ubiquitin-activating enzyme (E1) to a ubiquitin-conjugating enzyme (E2), producing a covalently linked intermediate (E2-Ub) . Ubiquitin ligases (E3s) of the...
10.
Kwasna D, Abdul Rehman S, Natarajan J, Matthews S, Madden R, De Cesare V, et al.
Mol Cell
. 2018 Mar;
70(1):150-164.e6.
PMID: 29576527
Deubiquitinating enzymes (DUBs) are important regulators of ubiquitin signaling. Here, we report the discovery of deubiquitinating activity in ZUFSP/C6orf113. High-resolution crystal structures of ZUFSP in complex with ubiquitin reveal several...