Author: Michael Kinter

1.

Afterload-induced Decreases in Fatty Acid Oxidation Develop Independently of Increased Glucose Utilization

Piristine H, May H, Jiang N, Daou D, Olivares-Silva F, Elnwasany A, et al.

bioRxiv . 2024 Sep; PMID: 39345412

Background: Metabolic substrate utilization in HFpEF (heart failure with preserved ejection fraction), the leading cause of heart failure worldwide, is pivotal to syndrome pathogenesis and yet remains ill defined. Under...

2.

NR2F2 Reactivation in Early-life Adipocyte Stem-like Cells Rescues Adipocyte Mitochondrial Oxidation

Das S, Varshney R, Farriester J, Kyere-Davies G, Martinez A, Hill K, et al.

bioRxiv . 2024 Sep; PMID: 39314382

In humans, perinatal exposure to an elevated omega-6 (n6) relative to omega-3 (n3) Fatty Acid (FA) ratio is associated with the likelihood of childhood obesity. In mice, we show perinatal...

3.

Loss of Cardiac PFKFB2 Drives Metabolic, Functional, and Electrophysiological Remodeling in the Heart

Harold K, Matsuzaki S, Pranay A, Loveland B, Batushansky A, Mendez Garcia M, et al.

J Am Heart Assoc . 2024 Mar; 13(7):e033676. PMID: 38533937

Background: Phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2) is a critical glycolytic regulator responsible for upregulation of glycolysis in response to insulin and adrenergic signaling. PFKFB2, the cardiac isoform of PFK-2, is degraded in the...

4.

Non-Necroptotic Roles of MLKL in Diet-Induced Obesity, Liver Pathology, and Insulin Sensitivity: Insights from a High-Fat, High-Fructose, High-Cholesterol Diet Mouse Model

Ohene-Marfo P, Nguyen H, Mohammed S, Thadathil N, Tran A, Nicklas E, et al.

Int J Mol Sci . 2024 Mar; 25(5). PMID: 38474061

Chronic inflammation is a key player in metabolic dysfunction-associated fatty liver disease (MAFLD) progression. Necroptosis, an inflammatory cell death pathway, is elevated in MAFLD patients and mouse models, yet its...

5.

Non-Necroptotic Roles of MLKL in Diet-Induced Obesity, Liver Pathology, and Insulin Sensitivity: Insights from a High Fat, High Fructose, High Cholesterol Diet Mouse Model

Ohene-Marfo P, Nguyen H, Mohammed S, Thadathil N, Tran A, Nicklas E, et al.

bioRxiv . 2024 Jan; PMID: 38260537

Chronic inflammation is a key player in metabolic dysfunction-associated fatty liver disease (MAFLD) progression. Necroptosis, an inflammatory cell death pathway, is elevated in MAFLD patients and mouse models, yet its...

6.

Loss of cardiac PFKFB2 drives Metabolic, Functional, and Electrophysiological Remodeling in the Heart

Harold K, Matsuzaki S, Pranay A, Loveland B, Batushansky A, Mendez Garcia M, et al.

bioRxiv . 2023 Dec; PMID: 38045353

Background: Phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2) is a critical glycolytic regulator responsible for upregulation of glycolysis in response to insulin and adrenergic signaling. PFKFB2, the cardiac isoform of PFK-2, is degraded in the...

7.

Postnatal hyperglycemia alters amino acid profile in retinas (model of Phase I ROP)

Harman J, Pivodic A, Nilsson A, Boeck M, Yagi H, Neilsen K, et al.

iScience . 2023 Oct; 26(10):108021. PMID: 37841591

Nutritional deprivation occurring in most preterm infants postnatally can induce hyperglycemia, a significant and independent risk factor for suppressing physiological retinal vascularization (Phase I retinopathy of prematurity (ROP)), leading to...

8.

Increased expression of BRD4 isoforms long (BRD4-L) and short (BRD4-S) promotes chemotherapy resistance in high-grade serous ovarian carcinoma

Drumond-Bock A, Wang L, Wang L, Cybula M, Rostworowska M, Kinter M, et al.

Genes Cancer . 2023 Sep; 14:56-76. PMID: 37705995

Chemoresistance in ovarian carcinoma is a puzzling issue that urges understanding of strategies used by cancer cells to survive DNA damage and to escape cell death. Expanding efforts to understand...

9.

Increased cardiac PFK-2 protects against high-fat diet-induced cardiomyopathy and mediates beneficial systemic metabolic effects

Mendez Garcia M, Matsuzaki S, Batushansky A, Newhardt R, Kinter C, Jin Y, et al.

iScience . 2023 Aug; 26(7):107131. PMID: 37534142

A healthy heart adapts to changes in nutrient availability and energy demands. In metabolic diseases like type 2 diabetes (T2D), increased reliance on fatty acids for energy production contributes to...

10.

Effects of Leptin and Body Weight on Inflammation and Knee Osteoarthritis Phenotypes in Female Rats

Fu Y, Batushansky A, Kinter M, Huebner J, Kraus V, Griffin T

JBMR Plus . 2023 Jul; 7(7):e10754. PMID: 37457883

Leptin is a proinflammatory adipokine that contributes to obesity-associated osteoarthritis (OA), especially in women. However, the extent to which leptin causes knee OA separate from the effect of increased body...