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Sathish Periyasamy

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Articles 14
Citations 1670
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Recent Articles
1.
Periyasamy S, Youssef P, John S, Thara R, Mowry B
Front Genet . 2024 Jan; 14:1301150. PMID: 38259618
The relationship between genotype and phenotype is governed by numerous genetic interactions (GIs), and the mapping of GI networks is of interest for two main reasons: 1) By modelling biological...
2.
Trubetskoy V, Pardinas A, Qi T, Panagiotaropoulou G, Awasthi S, Bigdeli T, et al.
Nature . 2022 Apr; 604(7906):502-508. PMID: 35396580
Schizophrenia has a heritability of 60-80%, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and...
3.
Periyasamy S, Mowry B
Front Mol Neurosci . 2022 Apr; 15:799801. PMID: 35392271
No abstract available.
4.
Pardinas A, Smart S, Willcocks I, Holmans P, Dennison C, Lynham A, et al.
JAMA Psychiatry . 2022 Jan; 79(3):260-269. PMID: 35019943
Importance: About 20% to 30% of people with schizophrenia have psychotic symptoms that do not respond adequately to first-line antipsychotic treatment. This clinical presentation, chronic and highly disabling, is known...
5.
Blokland G, Grove J, Chen C, Cotsapas C, Tobet S, Handa R, et al.
Biol Psychiatry . 2021 Jun; 91(1):102-117. PMID: 34099189
Background: Sex differences in incidence and/or presentation of schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BIP) are pervasive. Previous evidence for shared genetic risk and sex differences in...
6.
Legge S, Santoro M, Periyasamy S, Okewole A, Arsalan A, Kowalec K
Psychol Med . 2021 Feb; 51(13):2168-2177. PMID: 33550997
Schizophrenia is a severe psychiatric disorder with high heritability. Consortia efforts and technological advancements have led to a substantial increase in knowledge of the genetic architecture of schizophrenia over the...
7.
Lam M, Chen C, Li Z, Martin A, Bryois J, Ma X, et al.
Nat Genet . 2019 Nov; 51(12):1670-1678. PMID: 31740837
Schizophrenia is a debilitating psychiatric disorder with approximately 1% lifetime risk globally. Large-scale schizophrenia genetic studies have reported primarily on European ancestry samples, potentially missing important biological insights. Here, we...
8.
Peterson R, Kuchenbaecker K, Walters R, Chen C, Popejoy A, Periyasamy S, et al.
Cell . 2019 Oct; 179(3):589-603. PMID: 31607513
Genome-wide association studies (GWASs) have focused primarily on populations of European descent, but it is essential that diverse populations become better represented. Increasing diversity among study participants will advance our...
9.
Periyasamy S, John S, Padmavati R, Rajendren P, Thirunavukkarasu P, Gratten J, et al.
JAMA Psychiatry . 2019 Jul; 76(10):1026-1034. PMID: 31268507
Importance: Genome-wide association studies (GWASs) in European populations have identified more than 100 schizophrenia-associated loci. A schizophrenia GWAS in a unique Indian population offers novel findings. Objective: To discover and...
10.
Dzafic I, Burianova H, Periyasamy S, Mowry B
Psychiatry Res Neuroimaging . 2018 May; 276:33-40. PMID: 29723776
The neural correlates of emotion perception have been shown to be significantly altered in schizophrenia (SCZ) patients as well as their healthy relatives, possibly reflecting genetic susceptibility to the disease....