Saskia C A de Jager
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Explore the profile of Saskia C A de Jager including associated specialties, affiliations and a list of published articles.
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94
Citations
1962
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Recent Articles
1.
Kessler E, Canto E, Diez-Benavente E, van Ommen A, Kapteijn D, Glade M, et al.
Int J Cardiol
. 2025 Mar;
:133161.
PMID: 40088950
Background: Inflammatory conditions such as obesity and diabetes are linked to intermediate/non-classical monocyte activation, contributing to left ventricular diastolic dysfunction (LVDD) and heart failure with preserved ejection fraction (HFpEF). Objective:...
2.
Demkes E, Cervera-Barea A, Ebner-Peking P, Wolf M, Hochmann S, Scheren A, et al.
J Cardiovasc Transl Res
. 2025 Mar;
PMID: 40082315
Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) constitute a promising therapy for myocardial infarction (MI). The lack of an effective immunosuppressive regimen, combined with single-cell transplantations, results in suboptimal outcomes, such...
3.
Viola M, Bebelman M, Maas R, de Voogt W, Verweij F, Seinen C, et al.
J Extracell Vesicles
. 2024 Nov;
13(11):e70000.
PMID: 39508403
Extracellular vesicles (EVs) have emerged as important mediators of intercellular communication in the heart under homeostatic and pathological conditions, such as myocardial infarction (MI). However, the basic mechanisms driving cardiomyocyte-derived...
4.
Vervoorn M, van Tuijl S, Ballan E, Kaffka Genaamd Dengler S, de Jager S, Sluijter J, et al.
J Heart Lung Transplant
. 2024 Nov;
PMID: 39490458
Background: A common limitation to normothermic ex situ heart perfusion (ESHP) is functional decline. We previously designed a cardioprotective normothermic perfusion protocol, incorporating adenosine-lidocaine cardioplegia, subnormothermic reperfusion, pyruvate and methylprednisolone...
5.
Vervoorn M, Ballan E, Kaffka Genaamd Dengler S, Meijborg V, de Jager S, van Wijk R, et al.
J Heart Lung Transplant
. 2024 Oct;
44(2):285-288.
PMID: 39369969
Hypothermic oxygenated perfusion (HOPE) is an emerging technique for donor heart preservation that is currently being studied in multiple clinical trials with promising results. When compared to HOPE for other...
6.
Wulfse M, Vervoorn M, Amelink J, Ballan E, de Jager S, Sluijter J, et al.
J Cardiovasc Transl Res
. 2024 Oct;
18(1):209-220.
PMID: 39361114
Cell therapy, gene therapy, and tissue engineering have been explored as potential strategies to repair or regenerate damaged cardiac tissue. Despite the presence of encouraging preclinical data, clinical trials of...
7.
Hoekx C, Straat M, Bizino M, van Eyk H, Lamb H, Smit J, et al.
Exp Physiol
. 2024 Jul;
109(8):1292-1304.
PMID: 38965822
Glucagon-like peptide-1 receptor (GLP-1R) agonists induce weight loss in patients with type 2 diabetes mellitus (T2DM), but the underlying mechanism is unclear. Recently, the mechanism by which metformin induces weight...
8.
Ilahibaks N, Roefs M, Brans M, Blok C, de Jager S, Schiffelers R, et al.
J Extracell Biol
. 2024 Jun;
2(9):e97.
PMID: 38938374
Extracellular vesicles (EVs) are nanoscale particles that facilitate intercellular communication. They are regarded as a promising natural drug delivery system for transporting and delivering bioactive macromolecules to target cells. Recently,...
9.
Singh A, Kraaijeveld A, Curaj A, Wichapong K, Hammerich L, de Jager S, et al.
Front Immunol
. 2024 May;
15:1327051.
PMID: 38807599
Introduction: The CC chemokine ligand 18 (CCL18) is a chemokine highly expressed in chronic inflammation in humans. Recent observations of elevated CCL18 plasma levels in patients with acute cardiovascular syndromes...
10.
Hoekx C, Martinez-Tellez B, Straat M, Verkleij M, Kemmeren M, Kooijman S, et al.
Endocr Connect
. 2024 May;
13(7).
PMID: 38781402
Objectives: Cold exposure is linked to cardiometabolic benefits. Cold activates brown adipose tissue (BAT), increases energy expenditure, and induces secretion of the hormones fibroblast growth factor 21 (FGF21) and growth...